PMID- 11070406
OWN - NLM
STAT- MEDLINE
DCOM- 20001222
LR  - 20171101
IS  - 0012-2823 (Print)
IS  - 0012-2823 (Linking)
VI  - 62
IP  - 4
DP  - 2000
TI  - Relationship between ethanol-induced gastritis and gastric ulcer formation in 
      rats.
PG  - 232-9
AB  - BACKGROUND/AIMS: Patients with peptic ulcer diseases have a high prevalence of 
      coexisting chronic gastritis. The mechanism of how gastritis leads to gastric 
      ulcer formation is yet to be determined. The purpose of this study was to clarify 
      the relationship between gastritis and gastric ulcer in rats. METHODS: Ethanol 
      (80% v/v, p.o.) was given repeatedly in rats to induce subchronic gastritis. 
      Gastric ulcer was then induced by 60% acetic acid. RESULTS: Findings showed that 
      subchronic gastritis potentiated gastric ulcer formation. It also produced more 
      apoptotic cells, together with an overexpression of tumor necrosis factor-alpha 
      (TNF alpha) in the gastric mucosa. Inhibition of the production/release of TNF 
      alpha by pentoxifylline prevented the increase in apoptosis and the enhancement 
      of susceptibility to ulcerative damage by subchronic gastritis. However, such 
      subchronic gastritis did not further affect the rate of ulcer healing in these 
      animals. CONCLUSION: The induction of gastritis resulted in an activation of TNF 
      alpha expression followed by apoptosis in the gastric mucosa. This could lead to 
      an increase in the severity of ulcerative damage in the stomach.
CI  - Copyright 2000 S. Karger AG, Basel
FAU - Liu, E S
AU  - Liu ES
AD  - Department of Pharmacology, Faculty of Medicine, University of Hong Kong, China.
FAU - Cho, C H
AU  - Cho CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Central Nervous System Depressants/administration & dosage/*adverse effects
MH  - Disease Models, Animal
MH  - Ethanol/administration & dosage/*adverse effects
MH  - Gastric Mucosa/metabolism/pathology
MH  - Gastritis/*chemically induced/complications
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stomach Ulcer/*etiology
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 2000/11/09 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/09 11:00
PHST- 2000/11/09 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/09 11:00 [entrez]
AID - 7821 [pii]
AID - 10.1159/000007821 [doi]
PST - ppublish
SO  - Digestion. 2000;62(4):232-9. doi: 10.1159/000007821.