PMID- 11070509
OWN - NLM
STAT- MEDLINE
DCOM- 20010202
LR  - 20190915
IS  - 0104-4230 (Print)
IS  - 0104-4230 (Linking)
VI  - 46
IP  - 3
DP  - 2000 Jul-Sep
TI  - [Clinical findings of sensitivity to analgesics and nonsteroidal antiinflammatory 
      drugs].
PG  - 201-6
AB  - BACKGROUND: Analgesics (ANA) and nonsteroidal antiinflammatory drugs (NSAID) may 
      simulate an allergic reaction or aggravate asthma and urticaria. OBJECTIVE: The 
      aim of this study was the analysis of the clinical findings in patients sensitive 
      to ANA/NSAID. METHODS AND SUBJECTS: The charts of 183 patients with history of 
      reacting to these drugs were retrospectively analysed. RESULTS: There were 93 
      (51%) females and 90 (49%) males; 63 (34%) were aged 15 years or less. Females 
      predominate in the age group older than 15 years (p = 0,02). The age by the time 
      of the first reaction varied from 7 months to 65 years (median 15 years). Skin 
      tests to inhalant allergens were positive to at least one antigen in 100/138 
      patients (72%). Clinical presentation was angioedema (86%); urticaria (39%); 
      systemic reaction (30%); nasal and ocular (15%); and asthma (14%). The frequency 
      of symptoms was not related to age. Family history of ANA/NSAID sensitivity was 
      present in 3.8% of patients. Associated diseases were rhinitis (55%), chronic 
      urticaria (47%), asthma (37%) and conjuntivitis (18%). Among asthmatics 16 
      (23,5%) had had attacks with ANA/NSAID. Nine non asthmatics (7.7%) had had 
      bronchospasm as clinical presentation. This difference was statistically 
      significant. Repeated reactions occurred in 107 (58%) patients. CONCLUSIONS: 
      Sensitivity to ANA/NSAID was frequent in atopics; children and adults responded 
      similarly; reactions were more common in adult females; palpebral angioedema was 
      the most frequent clinical presentation; bronchosphasm was usually seen in 
      asthmatics and most patients reacted repeatedly to different drugs.
FAU - Rosario, N A
AU  - Rosario NA
AD  - Hospital de Clinicas, Universidade Federal do Parana, Curitiba, PR.
FAU - Ribeiro, A C
AU  - Ribeiro AC
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
TT  - Achados clinicos da sensibilidade a analgesicos e antiinflamatorios 
      nao-hormonais.
DEP - 20001116
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
RN  - 0 (Analgesics)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 6429L0L52Y (Dipyrone)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Acetaminophen/adverse effects
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Analgesics/*adverse effects
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
MH  - Aspirin/adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Dipyrone/adverse effects
MH  - Drug Eruptions/epidemiology/etiology
MH  - Drug Hypersensitivity/epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Skin Tests
EDAT- 2000/11/09 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/11/09 11:00
PHST- 2000/11/09 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/11/09 11:00 [entrez]
AID - S0104-42302000000300003 [pii]
AID - 10.1590/s0104-42302000000300003 [doi]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2000 Jul-Sep;46(3):201-6. doi: 
      10.1590/s0104-42302000000300003. Epub 2000 Nov 16.