PMID- 11071355
OWN - NLM
STAT- MEDLINE
DCOM- 20010215
LR  - 20191104
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 37
IP  - 4
DP  - 2000 Oct
TI  - Fluorescence in situ hybridization: uses and limitations.
PG  - 320-33
AB  - The development of molecular hybridization techniques such as fluorescence in 
      situ hybridization (FISH) has had a major Impact on efforts to detect and 
      characterize the genetic changes that give rise to human tumors. With probes 
      designed to Identify specific chromosomes and chromosomal regions, FISH is used 
      routinely by cytogenetics and pathology laboratories to identify recurring 
      chromosomal abnormalities associated with hematologic malignant diseases. In many 
      cases FISH analysis provides increased sensitivity, in that cytogenetic 
      abnormalities have been found In samples that appeared to be normal by 
      morphologic and conventional cytogenetic examination. The combination of 
      cytogenetic, FISH, and molecular analyses provides a powerful approach for 
      diagnosing and subclassifying malignant diseases into clinically and biologically 
      relevant subgroups, In selecting appropriate therapy, and in monitoring the 
      efficacy of therapeutic regimens.
FAU - Gozzetti, A
AU  - Gozzetti A
AD  - Department of Medicine, and The Cancer Research Center, University of Chicago, IL 
      60637, USA.
FAU - Le Beau, M M
AU  - Le Beau MM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
SB  - IM
MH  - Cytogenetic Analysis/*methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Neoplasms/genetics
MH  - Sensitivity and Specificity
RF  - 59
EDAT- 2000/11/09 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/11/09 11:00
PHST- 2000/11/09 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/11/09 11:00 [entrez]
AID - S0037196300000251 [pii]
AID - 10.1016/s0037-1963(00)90013-1 [doi]
PST - ppublish
SO  - Semin Hematol. 2000 Oct;37(4):320-33. doi: 10.1016/s0037-1963(00)90013-1.