PMID- 11071362
OWN - NLM
STAT- MEDLINE
DCOM- 20010215
LR  - 20191104
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 37
IP  - 4
DP  - 2000 Oct
TI  - Location and function of critical genes in leukemogenesis inferred from 
      cytogenetic abnormalities in hematologic malignancies.
PG  - 412-9
AB  - Dramatic advances in the cytogenetic analysis of chromosomal rearrangements of 
      hematopoietic malignancies have occurred over the past years. These are due to 
      considerable improvement in the techniques of molecular cytogenetics. Various 
      applications of fluorescence in situ hybridization (FISH), used in conjunction 
      with conventional cytogenetics, make the recognition of some abnormalities 
      easier, and the localization of chromosomal breakpoints in structural 
      rearrangements more precise. Under many circumstances, accurate breakpoint 
      localization is the first step toward the identification of genes involved in 
      translocations and inversions. Some of the genes recently discovered may be 
      rearranged with several partner genes. These promiscuous genes are natural 
      experiments that generate mutants which help to identify the function of genes 
      rearranged in hematopoietic malignancies as well as that of their normal 
      counterparts. The diversity of the genes implicated in leukemogenesis makes their 
      functional study a challenge, but, as recently shown by their role in chromatin 
      remodeling, increasing recognition of cross-talk between many of these genes 
      justifies the development of analyses of leukemia-associated chromosome 
      abnormalities and of their functional consequences.
FAU - Bernard, O A
AU  - Bernard OA
AD  - INSERM U434, Institut de Genetique Moleculaire, Paris, France.
FAU - Berger, R
AU  - Berger R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
SB  - IM
MH  - Cell Transformation, Neoplastic/genetics
MH  - *Chromosome Aberrations
MH  - *Chromosome Disorders
MH  - Cytogenetic Analysis
MH  - *Gene Rearrangement
MH  - Hematologic Neoplasms/*genetics
MH  - Humans
MH  - Leukemia/genetics
RF  - 59
EDAT- 2000/11/09 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/11/09 11:00
PHST- 2000/11/09 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/11/09 11:00 [entrez]
AID - S0037196300000329 [pii]
AID - 10.1016/s0037-1963(00)90020-9 [doi]
PST - ppublish
SO  - Semin Hematol. 2000 Oct;37(4):412-9. doi: 10.1016/s0037-1963(00)90020-9.