PMID- 11071363
OWN - NLM
STAT- MEDLINE
DCOM- 20010215
LR  - 20191104
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 37
IP  - 4
DP  - 2000 Oct
TI  - Integration of cytogenetic data with genome maps and available probes: present 
      status and future promise.
PG  - 420-8
AB  - The National Cancer Institute has established an initiative, called the Cancer 
      Chromosome Aberration Project (Ccap), in order to link and integrate the physical 
      and genetic maps of the human genome with cytogenetic data and the location of 
      chromosomal rearrangements in human diseases. This goal will be achieved by 
      high-resolution fluorescence in situ hybridization (FISH) mapping of 
      colony-purified bacterial artificial chromosome (BAC) clones spaced at 1-to 2-Mb 
      intervals across the entire genome. All BAC clones will be anchored on the 
      physical map by the presence of a mapped sequence tagged site (STS). The 
      generation of a publicly accessible clone repository will allow convenient 
      distribution of these BACs. Ccap data can be correlated with other 
      cancer-associated and genomic databases, such as the catalog of chromosomal 
      aberrations in cancer and the emerging full genomic sequence. We anticipate that 
      the use of Ccap clones will expedite and refine the mapping of chromosomal 
      breakpoints. The eventual set of approximately 3,000 Ccap BACs should facilitate 
      the production of BAC-containing DNA chips for assessing copy number of genomic 
      segments by matrix comparative genomic hybridization. In addition, the repository 
      will provide genome-wide tools for defining chromosomal aberrations in 
      cytological specimens by interphase cytogenetics. The Ccap Web site illustrates 
      goals and progress of this initiative (http://www.ncbi.nlm.nih.gov/CCAP/).
FAU - Kirsch, I R
AU  - Kirsch IR
AD  - Genetics Department, Medicine Branch, National Cancer Institute, National 
      Institutes of Health, Bethesda, MD 20889-5105, USA.
FAU - Ried, T
AU  - Ried T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
SB  - IM
MH  - *Chromosome Mapping
MH  - Cytogenetics
MH  - Databases, Factual/*trends
MH  - Forecasting
MH  - *Genome
MH  - Humans
MH  - Neoplasms/*genetics
RF  - 24
EDAT- 2000/11/09 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/11/09 11:00
PHST- 2000/11/09 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/11/09 11:00 [entrez]
AID - S0037196300000330 [pii]
AID - 10.1016/s0037-1963(00)90021-0 [doi]
PST - ppublish
SO  - Semin Hematol. 2000 Oct;37(4):420-8. doi: 10.1016/s0037-1963(00)90021-0.