PMID- 11071757
OWN - NLM
STAT- MEDLINE
DCOM- 20010104
LR  - 20061115
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 227
IP  - 2
DP  - 2000 Nov 15
TI  - The CNS midline cells coordinate proper cell cycle progression and identity 
      determination of the Drosophila ventral neuroectoderm.
PG  - 307-23
AB  - The CNS midline cells, specified by the single-minded (sim) gene, are required 
      for the proper patterning of the ventral CNS and epidermis, which are derived 
      from the Drosophila ventral neuroectoderm. Defects in the sim mutant are 
      characterized by the loss of the gene expression, which is required for the 
      proper formation of the ventral neurons and epidermis, and by a decrease in the 
      spacing of longitudinal and commissural axon tracks. Molecular and cellular 
      mechanisms for these defects were analyzed to elucidate the precise role of the 
      CNS midline cells in proper patterning of the ventral neuroectoderm during 
      embryonic neurogenesis. These analyses showed that the ventral neuroectoderm in 
      the sim mutant fails to carry out its proper formation and characteristic cell 
      division cycle. This resulted in the loss of the dividing neuroectodermal cells 
      that are located ventral to the CNS midline. The CNS midline cells are also 
      required for the cell cycle-independent expression of the neural and epidermal 
      markers. This indicates that the CNS midline cells are essential for the 
      establishment and maintenance of the ventral epidermal and neuronal cell lineage 
      by cell-cell interaction. On the other hand, the CNS midline cells do not cause 
      extensive cell death in the ventral neuroectoderm. This study indicates that the 
      CNS midline cells play important roles in the coordination of the proper cell 
      cycle progression and the correct identity determination of the adjacent ventral 
      neuroectoderm along the dorsoventral axis.
CI  - Copyright 2000 Academic Press.
FAU - Chang, J
AU  - Chang J
AD  - Department of Chemistry, Konkuk University, Seoul, 143-701, Korea.
FAU - Kim, I O
AU  - Kim IO
FAU - Ahn, J S
AU  - Ahn JS
FAU - Kwon, J S
AU  - Kwon JS
FAU - Jeon, S H
AU  - Jeon SH
FAU - Kim, S H
AU  - Kim SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Genetic Markers)
RN  - 0 (Nuclear Proteins)
RN  - 0 (sim protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Apoptosis/genetics
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Body Patterning/genetics
MH  - Cell Cycle
MH  - Cell Division
MH  - Central Nervous System/cytology/*embryology
MH  - DNA-Binding Proteins/*genetics
MH  - Drosophila/*embryology/*genetics
MH  - Drosophila Proteins
MH  - Ectoderm/cytology
MH  - Gene Expression Regulation, Developmental
MH  - *Genes, Insect
MH  - Genetic Markers
MH  - In Situ Hybridization
MH  - Models, Biological
MH  - Mutation
MH  - Nuclear Proteins/*genetics
EDAT- 2000/11/10 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/10 11:00
PHST- 2000/11/10 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/10 11:00 [entrez]
AID - S0012-1606(00)99905-6 [pii]
AID - 10.1006/dbio.2000.9905 [doi]
PST - ppublish
SO  - Dev Biol. 2000 Nov 15;227(2):307-23. doi: 10.1006/dbio.2000.9905.