PMID- 11074545
OWN - NLM
STAT- MEDLINE
DCOM- 20001130
LR  - 20190822
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 65
IP  - 3
DP  - 2000 Nov
TI  - Clinicopathological studies of a patient with adult T-cell leukemia and 
      pseudogynecomasty.
PG  - 256-9
AB  - We present a rare case of adult T cell leukemia/lymphoma (ATL) in which leukemic 
      T cells expressed CD4 and CD25 surface antigens and infiltrated mammary glands 
      during clinical course of the disease. A 40-year-old male was admitted with 
      long-standing skin lesions and leukocytosis. Peripheral blood lymphocytes were 
      highly pleomorphic and presented CD2, CD4, CD25, CD38 membrane surface antigens. 
      The patient proved to be seropositive for human T-cell lymphotropic virus type I 
      (HTLV-I) antibodies. Monoclonal expansion of lymphoid cells integrated with 
      HTLV-I genome was observed, and the diagnosis of ATL chronic type was made. He 
      underwent a chemotherapy regimen, and skin lesions and leukocytosis improved 
      markedly. He progressed with an indolent clinical course of ATL, when he was 
      admitted with bilateral hyperplasia of breast, recurrent skin lesions, and 
      leukocytosis. Breast biopsy revealed bilateral gynecomasty, extensive leukemic 
      infiltration of typical ATL cells in the mammary glands, and the presence of 
      mammary epithelial cells productively infected with HTLV-I. This is the first 
      report describing invasion of the mammary tissue with HTLV-I-transformed T-cells 
      and HTLV-I-associated breast disease.
FAU - Loureiro, P
AU  - Loureiro P
AD  - Department of Hematology, Hemocentro de Pernambuco, Recife, Brazil.
FAU - Southern, S O
AU  - Southern SO
FAU - Southern, P J
AU  - Southern PJ
FAU - Pombo-de-Oliveira, M S
AU  - Pombo-de-Oliveira MS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
SB  - IM
MH  - Breast/chemistry
MH  - Gynecomastia/complications/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Leukemia-Lymphoma, Adult T-Cell/complications/*pathology
MH  - Male
MH  - Middle Aged
EDAT- 2000/11/14 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/14 11:00
PHST- 2000/11/14 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/14 11:00 [entrez]
AID - 10.1002/1096-8652(200011)65:3<256::AID-AJH14>3.0.CO;2-V [pii]
AID - 10.1002/1096-8652(200011)65:3<256::aid-ajh14>3.0.co;2-v [doi]
PST - ppublish
SO  - Am J Hematol. 2000 Nov;65(3):256-9. doi: 
      10.1002/1096-8652(200011)65:3<256::aid-ajh14>3.0.co;2-v.