PMID- 11076337
OWN - NLM
STAT- MEDLINE
DCOM- 20010301
LR  - 20191104
IS  - 0167-482X (Print)
IS  - 0167-482X (Linking)
VI  - 21
IP  - 3
DP  - 2000 Sep
TI  - Changes in cerebral blood flow associated with premenstrual syndrome: a 
      preliminary study.
PG  - 157-65
AB  - The purpose of this study was to determine changes in regional cerebral blood 
      flow (rCBF) associated with premenstrual syndrome (PMS). Regional CBF was 
      examined using single photon emission computed tomography (SPECT) in seven women 
      who sought treatment for PMS and seven control subjects. Confirmation of PMS was 
      based on the Daily Symptom Report (DSR) of 17 common symptoms associated with 
      PMS. A first SPECT scan was performed near the peak of premenstrual symptoms 
      based on DSR reports from the two previous cycles. A second scan was performed in 
      the postmenstrual period. Prior to scanning, each subject had a Hamilton 
      Depression Rating Scale (Ham-D) obtained. Regions of interest were drawn on the 
      images to generate mean counts per pixel, and normalized to the cerebellum. 
      Activity in the frontal, temporal and parieto-occipital cortices, and the thalami 
      and basal ganglia, were compared between the two scans. Correlations between 
      activity in each region of interest and Ham-D values were also determined. There 
      were marked decreases in rCBF in the temporal lobes on the premenstrual scan 
      compared to the postmenstrual scan in PMS patients. Significant correlations were 
      observed between the change in rCBF in the right and left temporal lobes and the 
      changes in Ham-D scores (r = 0.91, p < 0.01 and r = 0.86, p = 0.01 respectively). 
      No rCBF changes were observed in controls. We conclude that SPECT imaging 
      demonstrates modest decreases in rCBF in the temporal lobes that correlate with 
      the level of depression in subjects with PMS.
FAU - Buchpiguel, C
AU  - Buchpiguel C
AD  - University of Sao Paulo, Brazil.
FAU - Alavi, A
AU  - Alavi A
FAU - Crawford, D
AU  - Crawford D
FAU - Freeman, E
AU  - Freeman E
FAU - Newberg, A
AU  - Newberg A
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Psychosom Obstet Gynaecol
JT  - Journal of psychosomatic obstetrics and gynaecology
JID - 8308648
SB  - IM
MH  - Adult
MH  - Blood Flow Velocity
MH  - Case-Control Studies
MH  - *Cerebrovascular Circulation
MH  - Depression/classification/diagnosis/etiology
MH  - Female
MH  - Humans
MH  - Premenstrual Syndrome/classification/complications/*diagnostic 
      imaging/*physiopathology/psychology
MH  - Psychiatric Status Rating Scales
MH  - Severity of Illness Index
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 2000/11/15 11:00
MHDA- 2001/03/07 10:01
CRDT- 2000/11/15 11:00
PHST- 2000/11/15 11:00 [pubmed]
PHST- 2001/03/07 10:01 [medline]
PHST- 2000/11/15 11:00 [entrez]
AID - 10.3109/01674820009075623 [doi]
PST - ppublish
SO  - J Psychosom Obstet Gynaecol. 2000 Sep;21(3):157-65. doi: 
      10.3109/01674820009075623.