PMID- 11078235
OWN - NLM
STAT- MEDLINE
DCOM- 20001130
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 85
IP  - 1
DP  - 2000 Jan 1
TI  - High carbohydrate diets, triglyceride-rich lipoproteins, and coronary heart 
      disease risk.
PG  - 45-8
AB  - In this study we compared the effects of variations in dietary fat and 
      carbohydrate (CHO) content on concentrations of triglyceride-rich lipoproteins in 
      8, healthy, nondiabetic volunteers. The diets contained, as a percentage of total 
      calories, either 60% CHO, 25% fat, and 15% protein, or 40% CHO, 45% fat, and 15% 
      protein. They were consumed in random order for 2 weeks, with a 2-week washout 
      period in between. Measurements were obtained at the end of each dietary period 
      of plasma triglyceride, cholesterol, low-density lipoprotein (LDL) cholesterol, 
      high-density lipoprotein (HDL) cholesterol, remnant lipoprotein (RLP) 
      cholesterol, and RLP triglyceride concentrations, both after an overnight fast 
      and throughout an 8-hour period (8 A.M. to 4 P.M.) in response to breakfast and 
      lunch. The 60% CHO diet resulted in higher (mean +/- SEM) fasting plasma 
      triglycerides (206 +/- 50 vs 113 +/- 19 mg/dl, p = 0.03), RLP cholesterol (15 +/- 
      6 vs 6 +/- 1 mg/dl, p = 0.005), RLP triglyceride (56 +/- 25 vs 16 +/- 3 mg/dl, p 
      = 0.003), and lower HDL cholesterol (39 +/- 3 vs 44 +/- 3 mg/dl, p = 0.003) 
      concentrations, without any change in LDL cholesterol concentration. Furthermore, 
      the changes in plasma triglyceride, RLP cholesterol, and RLP triglyceride 
      persisted throughout the day in response to breakfast and lunch. These results 
      indicate that the effects of lowfat diets on lipoprotein metabolism are not 
      limited to higher fasting plasma triglyceride and lower HDL cholesterol 
      concentrations, but also include a persistent elevation in RLPs. Given the 
      atherogenic potential of these changes in lipoprotein metabolism, it seems 
      appropriate to question the wisdom of recommending that all Americans should 
      replace dietary saturated fat with CHO.
FAU - Abbasi, F
AU  - Abbasi F
AD  - Stanford University School of Medicine, California, USA.
FAU - McLaughlin, T
AU  - McLaughlin T
FAU - Lamendola, C
AU  - Lamendola C
FAU - Kim, H S
AU  - Kim HS
FAU - Tanaka, A
AU  - Tanaka A
FAU - Wang, T
AU  - Wang T
FAU - Nakajima, K
AU  - Nakajima K
FAU - Reaven, G M
AU  - Reaven GM
LA  - eng
GR  - HL-08506/HL/NHLBI NIH HHS/United States
GR  - RR-00070/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Apolipoproteins)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Lipoproteins)
RN  - 0 (Triglycerides)
RN  - 0 (remnant-like particle cholesterol)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Apolipoproteins/*blood
MH  - Cholesterol/*blood
MH  - Cholesterol, HDL/*blood
MH  - Cholesterol, LDL/blood
MH  - Coronary Disease/*etiology
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/*administration & dosage/*adverse effects
MH  - Dietary Fats/*administration & dosage/*adverse effects
MH  - *Energy Intake
MH  - Fasting
MH  - Female
MH  - Humans
MH  - Lipoproteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Nutrition Policy
MH  - Time Factors
MH  - Triglycerides/*blood
EDAT- 2000/11/15 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/15 11:00
PHST- 2000/11/15 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/15 11:00 [entrez]
AID - S0002-9149(99)00604-9 [pii]
AID - 10.1016/s0002-9149(99)00604-9 [doi]
PST - ppublish
SO  - Am J Cardiol. 2000 Jan 1;85(1):45-8. doi: 10.1016/s0002-9149(99)00604-9.