PMID- 11084095
OWN - NLM
STAT- MEDLINE
DCOM- 20051220
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 86
IP  - 9A
DP  - 2000 Nov 2
TI  - Multisite atrial pacing: an option for atrial fibrillation prevention? 
      Preliminary results of the Dutch Dual-site Right Atrial Pacing for Prevention of 
      Atrial Fibrillation study.
PG  - 20K-24K
AB  - Multisite pacing is a novel concept for the prevention of recurrent 
      drug-refractory atrial fibrillation (AF). Two different pacing methods have been 
      described, biatrial pacing and dual-site right atrial stimulation. The use of 
      multisite pacing as preventive therapy for recurrences of atrial fibrillation is 
      still under investigation. We conducted a prospective, randomized, crossover 
      study in patients with recurrent drug-refractory AF without or with minimal 
      structural heart disease. After implantation of a DDD pacemaker, patients were 
      randomized to either dual-site pacing first (Group I) or single-site (high right 
      atrium) pacing first (Group II) and, after 6 months of treatment, the device was 
      reprogrammed to the other pacing mode. Preliminary results of 13 patients in each 
      group are presented. Clinical characteristics of patients in both groups with 
      respect to age, sex, left atrial dimension, left ventricular function, and New 
      York Heart Association (NYHA) functional class were comparable. Pacing therapy 
      was combined with antiarrhythmic drug treatment. After completion of the study 
      protocol, the arrhythmia-free interval was not remarkably different in either 
      group. However, the endpoint free interval (i.e., the need for electrical 
      cardioversion because of recurrent AF lasting >24 hours, was less during 
      dual-site pacing in Group II. Within 6 months, 43 patients enrolled in this study 
      will have completed the protocol.
FAU - Ramdat Misier, A R
AU  - Ramdat Misier AR
AD  - Department of Cardiology, Isala Klinieken, Zwolle, The Netherlands.
FAU - Beukema, W P
AU  - Beukema WP
FAU - Oude Luttikhuis, H A
AU  - Oude Luttikhuis HA
FAU - Willems, R
AU  - Willems R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/*prevention & control/therapy
MH  - Cardiac Pacing, Artificial/*methods
MH  - Cross-Over Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Prospective Studies
MH  - Secondary Prevention
MH  - Treatment Outcome
EDAT- 2000/11/21 00:00
MHDA- 2005/12/21 09:00
CRDT- 2000/11/21 00:00
PHST- 2000/11/21 00:00 [pubmed]
PHST- 2005/12/21 09:00 [medline]
PHST- 2000/11/21 00:00 [entrez]
AID - S0002914900011875 [pii]
AID - 10.1016/s0002-9149(00)01187-5 [doi]
PST - ppublish
SO  - Am J Cardiol. 2000 Nov 2;86(9A):20K-24K. doi: 10.1016/s0002-9149(00)01187-5.