PMID- 11084220
OWN - NLM
STAT- MEDLINE
DCOM- 20010116
LR  - 20190826
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 96
IP  - 3
DP  - 2000 Nov 20
TI  - The effects of noradrenaline and alpha-2 adrenoceptor agents on the production of 
      monocytic products.
PG  - 245-53
AB  - There are some reports that catecholamines may modulate the production of 
      monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha 
      (TNF alpha). The present study was carried out in order to examine the effects of 
      noradrenaline (10(-5), 10(-6) and 10(-7) M), clonidine (10(-5), 10(-6) and 10(-7) 
      M), an alpha2-adrenoceptor agonist, and yohimbine (10(-5), 10(-6) and 10(-7) M), 
      an alpha 2-adrenoceptor antagonist, on the production of IL-6, the IL-1 receptor 
      antagonist (IL-1RA) and TNF alpha by stimulated whole blood of normal humans. We 
      measured the in vitro production of IL-6, TNF alpha and IL-1RA by stimulated 
      (phytohemagglutinin+lipopolysaccharide), diluted whole blood of 16 normal 
      volunteers. The results show that noradrenaline, 10(-5) M, significantly 
      suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, 
      significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 
      10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 
      10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. It is 
      concluded that (1) noradrenaline has significant negative immunoregulatory 
      effects in humans through suppression of the production of (monocytic) 
      proinflammatory cytokines, e.g. IL-6 and TNF alpha, and (2) the suppression of 
      the production of TNF alpha may be related to alpha(2)-adrenoceptor-related 
      mechanisms.
FAU - Maes, M
AU  - Maes M
AD  - Department of Psychiatry & Neuropsychology, University Hospital of Maastricht, 
      P.O. Box 5800, AZ 6202 Maastricht, The Netherlands. crc-mh@online.be
FAU - Lin, A
AU  - Lin A
FAU - Kenis, G
AU  - Kenis G
FAU - Egyed, B
AU  - Egyed B
FAU - Bosmans, E
AU  - Bosmans E
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Adrenergic alpha-2 Receptor Agonists)
RN  - 0 (Adrenergic alpha-2 Receptor Antagonists)
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (IL1RN protein, human)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (Sialoglycoproteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 2Y49VWD90Q (Yohimbine)
RN  - MN3L5RMN02 (Clonidine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - *Adrenergic alpha-2 Receptor Agonists
MH  - *Adrenergic alpha-2 Receptor Antagonists
MH  - Adrenergic alpha-Agonists/pharmacology
MH  - Adrenergic alpha-Antagonists/pharmacology
MH  - Adult
MH  - Clonidine/pharmacology
MH  - Female
MH  - Humans
MH  - Immune Tolerance
MH  - Immunosuppressive Agents/metabolism
MH  - In Vitro Techniques
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-6/*biosynthesis
MH  - Male
MH  - Middle Aged
MH  - Monocytes/drug effects/*metabolism
MH  - Norepinephrine/*metabolism
MH  - Sialoglycoproteins/*biosynthesis/drug effects
MH  - Stress, Psychological/immunology/*metabolism
MH  - Tumor Necrosis Factor-alpha/*biosynthesis/drug effects
MH  - Yohimbine/pharmacology
EDAT- 2000/11/21 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/21 11:00
PHST- 2000/11/21 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/21 11:00 [entrez]
AID - S0165-1781(00)00216-X [pii]
AID - 10.1016/s0165-1781(00)00216-x [doi]
PST - ppublish
SO  - Psychiatry Res. 2000 Nov 20;96(3):245-53. doi: 10.1016/s0165-1781(00)00216-x.