PMID- 11084387
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 5
IP  - 11
DP  - 2000 Nov 1
TI  - Voltage-gated sodium channels as therapeutic targets.
PG  - 506-520
AB  - Voltage-gated sodium channels (VGSCs) play a central role in the generation and 
      propagation of action potentials in neurons and other cells. VGSC modulators have 
      their origins in empirical pharmacology and are being used as local anaesthetics, 
      antiarrhythmics, analgesics and antiepileptics, and for other disorders. However, 
      the identification of a multigene family of VGSCs, along with tools to study the 
      different subtypes in pathophysiology, is now providing a rational basis for 
      selective intervention. Recent advances have addressed the technical challenges 
      of expressing and assaying these complex proteins, enabling the correlation of 
      empirical pharmacology to subtypes and the screening of individual subtypes for 
      novel inhibitors with increased potency and selectivity.
FAU - Clare, JJ
AU  - Clare JJ
AD  - Molecular Pharmacology, GlaxoWellcome R&D, Gunnels Wood Road, SG1 2NY., 
      Stevenage, UK
FAU - Tate, SN
AU  - Tate SN
FAU - Nobbs, M
AU  - Nobbs M
FAU - Romanos, MA
AU  - Romanos MA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
EDAT- 2000/11/21 00:00
MHDA- 2000/11/21 00:01
CRDT- 2000/11/21 00:00
PHST- 2000/11/21 00:00 [pubmed]
PHST- 2000/11/21 00:01 [medline]
PHST- 2000/11/21 00:00 [entrez]
AID - S1359-6446(00)01570-1 [pii]
AID - 10.1016/s1359-6446(00)01570-1 [doi]
PST - ppublish
SO  - Drug Discov Today. 2000 Nov 1;5(11):506-520. doi: 10.1016/s1359-6446(00)01570-1.