PMID- 11085368
OWN - NLM
STAT- MEDLINE
DCOM- 20030404
LR  - 20190719
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 23
IP  - 11
DP  - 2000 Nov
TI  - Antiallergic effect of apple polyphenols on the allergic model mouse.
PG  - 1370-3
AB  - We studied here the antiallergic effect of apple condensed tannins (ACT) 
      administered orally to a type I allergy model mouse transplanted with an IgEL a2 
      hybridoma secreting anti-2,4,6-trinitrophenyl (TNP) immunoglobulin E (IgE). The 
      oral administration of ACT significantly inhibited the ear swelling responses at 
      1 h after antigen-stimulation with picryl chloride. The response was dose 
      dependent within 0.1 to 10 mg/mouse. The inhibition of the ear swelling response 
      reached the maximal level (90% inhibition) when ACT was administered 2 h before 
      the antigen challenge. These findings suggest that ACT has an antiallergic effect 
      on type I allergic symptoms.
FAU - Akiyama, H
AU  - Akiyama H
AD  - National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 
      158-8501, Japan.
FAU - Sakushima, J
AU  - Sakushima J
FAU - Taniuchi, S
AU  - Taniuchi S
FAU - Kanda, T
AU  - Kanda T
FAU - Yanagida, A
AU  - Yanagida A
FAU - Kojima, T
AU  - Kojima T
FAU - Teshima, R
AU  - Teshima R
FAU - Kobayashi, Y
AU  - Kobayashi Y
FAU - Goda, Y
AU  - Goda Y
FAU - Toyoda, M
AU  - Toyoda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Flavonoids)
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Phenols)
RN  - 0 (Polymers)
RN  - 0 (Polyphenols)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - X49220T18G (Ketotifen)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Ear, External/pathology
MH  - Edema/drug therapy/pathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - *Flavonoids
MH  - Histamine H1 Antagonists/pharmacology
MH  - Hybridomas/pathology
MH  - Hypersensitivity/*drug therapy/pathology
MH  - Immunoglobulin E/immunology
MH  - Ketotifen/pharmacology
MH  - Malus/*chemistry
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Phenols/chemistry/*pharmacology
MH  - Polymers/chemistry/*pharmacology
MH  - Polyphenols
EDAT- 2000/11/21 00:00
MHDA- 2003/04/05 05:00
CRDT- 2000/11/21 00:00
PHST- 2000/11/21 00:00 [pubmed]
PHST- 2003/04/05 05:00 [medline]
PHST- 2000/11/21 00:00 [entrez]
AID - 10.1248/bpb.23.1370 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2000 Nov;23(11):1370-3. doi: 10.1248/bpb.23.1370.