PMID- 11086442
OWN - NLM
STAT- MEDLINE
DCOM- 20001207
LR  - 20131121
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 27
IP  - 12
DP  - 2000 Oct
TI  - [Hepatic arterial injection of degradable starch microspheres (DSM) combined with 
      adriamycin (ADM) and mitomycin C (MMC) in patients with liver metastasis of 
      colorectal cancer].
PG  - 1904-6
AB  - We evaluated the adverse effects, response rates, and changes in CEA-doubling 
      time before and during DSM.ADM.MMC therapy (DSM therapy) in 8 patients with liver 
      metastases of colorectal cancer. In principle, 600 mg/body DSM, 30 mg/body ADM, 
      and 10 mg/body MMC were injected into the hepatic artery, and this treatment was 
      repeated as often as possible. A total of 26 injections revealed no severe 
      adverse effects. In 5 patients who received 3 or more injections of DSM, the 
      response rate was 20% (partial response, one) and an improvement of CEA-doubling 
      time was confirmed in 3 patients (60%). Two patients who demonstrated the 
      shortening of CEA-doubling time after this therapy had shorter survival. It is 
      suggested that to compare CEA-doubling times before and during DSM therapy is 
      useful for selecting candidates for this treatment.
FAU - Takeuchi, I
AU  - Takeuchi I
AD  - Dept. of Surgery, Saitama Medical Center, Saitama Medical School.
FAU - Ishida, H
AU  - Ishida H
FAU - Inokuma, S
AU  - Inokuma S
FAU - Nakada, H
AU  - Nakada H
FAU - Oosawa, T
AU  - Oosawa T
FAU - Sakimoto, T
AU  - Sakimoto T
FAU - Hashimoto, D
AU  - Hashimoto D
FAU - Kashimada, A
AU  - Kashimada A
FAU - Osada, H
AU  - Osada H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 50SG953SK6 (Mitomycin)
RN  - 80168379AG (Doxorubicin)
RN  - 9005-25-8 (Starch)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Colorectal Neoplasms/*pathology
MH  - Doxorubicin/administration & dosage
MH  - Drug Administration Schedule
MH  - Female
MH  - Hepatic Artery
MH  - Humans
MH  - Infusions, Intra-Arterial
MH  - Liver Neoplasms/*drug therapy/mortality/*secondary
MH  - Male
MH  - Microspheres
MH  - Middle Aged
MH  - Mitomycin/administration & dosage
MH  - Starch/administration & dosage
MH  - Survival Rate
EDAT- 2000/11/22 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/22 11:00
PHST- 2000/11/22 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/22 11:00 [entrez]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2000 Oct;27(12):1904-6.