PMID- 11089886
OWN - NLM
STAT- MEDLINE
DCOM- 20001211
LR  - 20191025
IS  - 0262-0898 (Print)
IS  - 0262-0898 (Linking)
VI  - 17
IP  - 10
DP  - 1999
TI  - Simultaneous up-regulation of urokinase-type plasminogen activator (uPA) and uPA 
      receptor by hepatocyte growth factor/scatter factor in human glioma cells.
PG  - 873-9
AB  - Several lines of evidence indicate that hepatocyte growth factor/scatter factor 
      (HGF/SF) and its receptor, c-Met, may play an important role in progression of 
      human glioma. In this study, effects of HGF/SF on urokinase- type plasminogen 
      activator (uPA)-mediated proteolysis network were examined in c-Met-positive 
      human glioma cell lines. Treatment of the glioma cells with various 
      concentrations of HGF/SF resulted in an enhanced secretion of uPA proteins 
      accompanying increased transcription of uPA mRNA in a dose dependent fashion. The 
      levels of uPA receptor (uPAR) mRNAs were also elevated simultaneously upon HGF/SF 
      stimulation, and the cell-surface associated uPA activity was also elevated by 
      the treatment. Since concomitant expression of HGF and its receptor c-Met are 
      frequently observed in malignant gliomas, these results suggest that HGF/SF 
      participates in invasive process of malignant glioma cells not only by its 
      motility-stimulating activity but also through enhanced degradation of the 
      extracellular matrix induced by autocrine activation of uPA proteolysis network.
FAU - Moriyama, T
AU  - Moriyama T
AD  - Department of Neurosurgery, Miyazaki Medical College, Kiyotake, Japan.
FAU - Kataoka, H
AU  - Kataoka H
FAU - Hamasuna, R
AU  - Hamasuna R
FAU - Yoshida, E
AU  - Yoshida E
FAU - Sameshima, T
AU  - Sameshima T
FAU - Iseda, T
AU  - Iseda T
FAU - Yokogami, K
AU  - Yokogami K
FAU - Nakano, S
AU  - Nakano S
FAU - Koono, M
AU  - Koono M
FAU - Wakisaka, S
AU  - Wakisaka S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Exp Metastasis
JT  - Clinical & experimental metastasis
JID - 8409970
RN  - 0 (Oligopeptides)
RN  - 0 (PLAUR protein, human)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Urokinase Plasminogen Activator)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 74661-31-7 (5-oxo-prolyl-glycyl-arginine-4-nitroanilide)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
SB  - IM
MH  - Central Nervous System Neoplasms/drug therapy/*metabolism
MH  - Glioma/drug therapy/*metabolism
MH  - Hepatocyte Growth Factor/*metabolism/pharmacology
MH  - Humans
MH  - Oligopeptides/metabolism
MH  - Proto-Oncogene Proteins c-met/metabolism
MH  - Receptors, Cell Surface/drug effects/genetics/*metabolism
MH  - Receptors, Urokinase Plasminogen Activator
MH  - Tumor Cells, Cultured
MH  - Up-Regulation
MH  - Urokinase-Type Plasminogen Activator/drug effects/genetics/*metabolism
EDAT- 2000/11/23 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/23 11:00
PHST- 2000/11/23 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/23 11:00 [entrez]
AID - 10.1023/a:1006729611241 [doi]
PST - ppublish
SO  - Clin Exp Metastasis. 1999;17(10):873-9. doi: 10.1023/a:1006729611241.