PMID- 11090889
OWN - NLM
STAT- MEDLINE
DCOM- 20010108
LR  - 20190826
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 116
IP  - 1
DP  - 2000 Nov 15
TI  - Critical periods for the effects of alcohol exposure on brain weight, body 
      weight, activity and investigation.
PG  - 99-110
AB  - Using an animal model of fetal alcohol syndrome - which equates peak blood 
      alcohol concentrations across different developmental periods - critical periods 
      for the effect of alcohol on brain weight, activity and investigative behavior 
      were examined. The periods of alcohol exposure were from gestational day (GD) 1 
      through 10, GD 11 through 22, postnatal day (PD) 2 through 10, or all three 
      periods combined. The critical period of alcohol exposure for an increase in 
      activity in juveniles was GD 11 through 22. This pattern was not seen in the same 
      animals in adulthood; instead, increases in both activity and investigation were 
      seen in animals exposed from PD 2 through 10 and not seen in animals exposed 
      during all three periods combined. Brain weight was reduced by alcohol exposure 
      from GD 11 through 22, PD 2 through 10 and all three periods combined. The period 
      from PD 2 through 10 was the only period when the brain weight to body weight 
      ratio was reduced. In conclusion, exposure to alcohol during the periods in the 
      latter half of gestation or early postnatal period seem to have the most 
      deleterious effects on the brain, activity and investigation in the rat. In 
      addition, the effects of alcohol exposure over both the prenatal and postnatal 
      period cannot be easily predicted from the effects of shorter periods of 
      exposure.
FAU - Tran, T D
AU  - Tran TD
AD  - Department of Psychology, University of South Carolina, Columbia, SC 29208, USA.
FAU - Cronise, K
AU  - Cronise K
FAU - Marino, M D
AU  - Marino MD
FAU - Jenkins, W J
AU  - Jenkins WJ
FAU - Kelly, S J
AU  - Kelly SJ
LA  - eng
GR  - AA11566/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Body Weight/*drug effects
MH  - Brain/*drug effects/*growth & development
MH  - Central Nervous System Depressants/blood/*toxicity
MH  - Ethanol/blood/*toxicity
MH  - Exploratory Behavior/*drug effects
MH  - Female
MH  - Male
MH  - Microcephaly/chemically induced/pathology
MH  - Motor Activity/*drug effects
MH  - Rats
MH  - Rats, Long-Evans
EDAT- 2000/11/25 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/25 11:00
PHST- 2000/11/25 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/25 11:00 [entrez]
AID - S0166-4328(00)00263-1 [pii]
AID - 10.1016/s0166-4328(00)00263-1 [doi]
PST - ppublish
SO  - Behav Brain Res. 2000 Nov 15;116(1):99-110. doi: 10.1016/s0166-4328(00)00263-1.