PMID- 11091274
OWN - NLM
STAT- MEDLINE
DCOM- 20001214
LR  - 20190513
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 122
IP  - 2
DP  - 2000 Nov
TI  - CXC chemokines Gro(alpha)/IL-8 and IP-10/MIG in Helicobacter pylori gastritis.
PG  - 192-9
AB  - Infection with Helicobacter pylori causes chronic active gastritis, which is 
      characterized by neutrophils infiltrating the gastric epithelial layer and the 
      underlying lamina propria as well as by T, B lymphocytes and macrophages 
      accumulating in the lamina propria. In this study, the chemokine profile 
      responsible for the recruitment of these inflammatory cells is investigated. 
      Using both RNA/RNA in situ hybridization and immunohistochemistry, the expression 
      of the neutrophil and/or lymphocyte-attractant CXC chemokines growth-related 
      oncogene alpha (Gro(alpha)), IL-8, interferon-gamma (IFN-gamma)-inducible 
      protein-10 (IP-10), monokine induced by IFN-gamma (MIG) and the CC chemokines 
      macrophage inflammatory protein-1alpha (MIP-1alpha), -1beta, regulated on 
      activation normal T cell expressed and secreted (RANTES) and monocyte 
      chemoattractant protein-1 (MCP-1) is studied and microanatomically localized in 
      the gastric mucosa. Macrophages in the lamina propria at sites with neutrophil 
      infiltration and gastric epithelium infiltrated by neutrophils highly expressed 
      the neutrophil-attractant chemokines Gro(alpha) and IL-8. Additionally, 
      Gro(alpha) and IL-8 were expressed by neutrophils themselves localized within 
      gastric epithelium, in the foveolar lumen and in the cellular debris overlying 
      mucosal erosion. IP-10 and to a lower extent MIG, both selectively chemotactic 
      for inflammatory T cells, were expressed by endothelial cells of gastric mucosal 
      vessels and by mononuclear cells at sites with T cell infiltration. Expression of 
      all other CC chemokines tested was significantly lower. These in vivo data 
      indicate that a set of predominantly CXC chemokines modulates the inflammation in 
      H. pylori gastritis. Gro(alpha) and IL-8 may play an important role in neutrophil 
      trafficking from the mucosal vessel into the gastric epithelium, whereas IP-10 
      and MIG contribute to the recruitment of inflammatory T cells into the mucosa.
FAU - Eck, M
AU  - Eck M
AD  - Institut fur Pathologie, Universitat Wurzburg, Germany. Matth.Eck@gmx.de
FAU - Schmausser, B
AU  - Schmausser B
FAU - Scheller, K
AU  - Scheller K
FAU - Toksoy, A
AU  - Toksoy A
FAU - Kraus, M
AU  - Kraus M
FAU - Menzel, T
AU  - Menzel T
FAU - Muller-Hermelink, H K
AU  - Muller-Hermelink HK
FAU - Gillitzer, R
AU  - Gillitzer R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (CXCL1 protein, human)
RN  - 0 (CXCL9 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokine CXCL1)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokine CXCL9)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Growth Substances)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin-8)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Chemokine CCL2/genetics/metabolism
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CCL5/genetics/metabolism
MH  - Chemokine CXCL1
MH  - Chemokine CXCL10
MH  - Chemokine CXCL9
MH  - Chemokines, CXC/*genetics/*metabolism
MH  - Chemotactic Factors/genetics/metabolism
MH  - Gastric Mucosa/immunology/pathology
MH  - Gastritis/genetics/*immunology/pathology
MH  - Gene Expression
MH  - Growth Substances/genetics/metabolism
MH  - Helicobacter Infections/genetics/*immunology/pathology
MH  - *Helicobacter pylori
MH  - Humans
MH  - In Situ Hybridization
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Interleukin-8/genetics/metabolism
MH  - Macrophage Inflammatory Proteins/genetics/metabolism
MH  - Neutrophils/immunology
MH  - RNA, Messenger/genetics/metabolism
MH  - T-Lymphocytes/immunology
PMC - PMC1905774
EDAT- 2000/11/25 11:00
MHDA- 2001/02/28 10:01
PMCR- 2001/11/01
CRDT- 2000/11/25 11:00
PHST- 2000/11/25 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/25 11:00 [entrez]
PHST- 2001/11/01 00:00 [pmc-release]
AID - cei1374 [pii]
AID - 10.1046/j.1365-2249.2000.01374.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2000 Nov;122(2):192-9. doi: 10.1046/j.1365-2249.2000.01374.x.