PMID- 11091746
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1880-4233 (Electronic)
IS  - 1340-6868 (Linking)
VI  - 6
IP  - 4
DP  - 1999 Oct 25
TI  - New Prognostic Factors Associated with Long-term Survival in Node-Negative Breast 
      Cancer Patients.
PG  - 370-377
AB  - BACKGROUND: This study was undertaken to determine the absolute and relative 
      value of angiogenesis, proliferating cell nuclear antigen (PCNA) and conventional 
      prognostic factors in predicting relapse-free survival (RFS) and overall survival 
      (OS) rates associated with long-term survival in Japanese patients with 
      node-negative breast cancer. PATIENTS AND METHODS: Two hundred patients with 
      histological node-negative breast cancer were studied. We investigated nine 
      clinicopathological factors, including angiogenesis, PCNA using 
      per-manent-section immunohistochemistry, clinicaltumor size, histological grade 
      (HG), tumor necrosis, lymphatic vessel invasion (LVI), histological extension, 
      histological classification, and infiltrating growth (INF), followed for a median 
      of 10 years (range, 1 to 20). RESULTS: Twenty-one patients (10.5%) had recurrence 
      and 15 patients (7.5%) died of breast cancer. Univariate analysis showed that 
      PCNA, clinical tumor size, HG, angiogenesis, and LVI were significantly 
      predictive of 20-year RFS or OS. Tumor necrosis was significantly predictive of 
      OS, not of RFS. Multi-variate analysis showed that clinical tumor size (P = 
      0.0003), angiogenesis (P = 0.0003), PCNA (P = 0.0064), and HG (P = 0.0401) were 
      significant independent prognostic factors for RFS. PCNA (P< 0.0001) and clinical 
      tumor size (P = 0.0112) were significant independent prognostic factors for OS, 
      while angiogenesis was a borderline significant factor. CONCLUSION: PCNA and 
      angiogenesis were important new prognostic factors in node-negative breast cancer 
      patients.
FAU - Kato, T
AU  - Kato T
AD  - Departments of Surgery II, School of Medicine, Tokoy Women's Medical University, 
      8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
FAU - Kimura, T
AU  - Kimura T
FAU - Takami, N
AU  - Takami N
FAU - Miyakawa, R
AU  - Miyakawa R
FAU - Tanaka, S
AU  - Tanaka S
FAU - Muraki, H
AU  - Muraki H
FAU - Kamio, T
AU  - Kamio T
FAU - Fujii, A
AU  - Fujii A
FAU - Yamamoto, K
AU  - Yamamoto K
FAU - Kameoka, S
AU  - Kameoka S
FAU - Nishikawa, T
AU  - Nishikawa T
FAU - Kasajima, T
AU  - Kasajima T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Breast Cancer
JT  - Breast cancer (Tokyo, Japan)
JID - 100888201
EDAT- 2000/11/25 00:00
MHDA- 2000/11/25 00:01
CRDT- 2000/11/25 00:00
PHST- 2000/11/25 00:00 [pubmed]
PHST- 2000/11/25 00:01 [medline]
PHST- 2000/11/25 00:00 [entrez]
AID - 10.1007/BF02966456 [doi]
PST - ppublish
SO  - Breast Cancer. 1999 Oct 25;6(4):370-377. doi: 10.1007/BF02966456.