PMID- 11093432
OWN - NLM
STAT- MEDLINE
DCOM- 20010329
LR  - 20061115
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 27
IP  - 11
DP  - 2000 Nov
TI  - The effect of disease activity related cytokines on the fibrinolytic potential 
      and cICAM-1 expression in rheumatoid arthritis.
PG  - 2545-50
AB  - OBJECTIVE: We studied the relation of pro and antiinflammatory cytokines to 
      disease activity, coagulation, and fibrinolytic variables as well as to 
      circulating intercellular adhesive molecule- 1 (cICAM-1), so as to better 
      understand the cascade of events implicated in the inflammatory process in 
      rheumatoid arthritis (RA). METHODS: Tumor necrosis factor-alpha (TNF-alpha), 
      interleukin (IL)-6, IL-10, cICAM-1, tissue-type plasminogen activator (t-PA), 
      plasminogen activator inhibitor- 1 (PAI-1), and D-dimer antigens were measured by 
      ELISA in the blood of 45 RA patients and 33 healthy subjects (HS). The Stoke 
      Index was used to describe the disease activity in patients, who were divided 
      into subgroups: A: minimal-mild disease activity (n = 23, Stoke Index = 1-7); B: 
      moderate disease activity (n = 12, Stoke Index = 8-11); C: severe disease 
      activity (n = 9, Stoke Index = 12-17). RESULTS: TNF-alpha, IL-6, and IL-10 were 
      significantly higher in RA patients than in HS. TNF-alpha and IL-6, in contrast 
      to IL-10, have the tendency to increase progressively with the increase of 
      disease activity from subgroup to subgroup, correlating significantly with Stoke 
      Index. TNF-alpha and IL-6 correlated positively with PAI-1 and negatively with 
      t-PA and D-dimer. Moreover, a positive correlation of IL-6 with fibrinogen and of 
      both cytokines with PAI-1/t-PA molar ratio were found in all RA patients, while 
      IL-10 showed a significant negative correlation only with PAI-1. Serum cICAM-1 
      was significantly elevated in RA compared to HS, showing a tendency to increase 
      with the increase of disease activity from subgroup to subgroup. A positive 
      correlation of cICAM-1 with TNF-alpha and IL-6 and a negative one with IL-10 was 
      observed in RA. CONCLUSION: Proinflammatory cytokines TNF-alpha and IL-6 may be 
      implicated in the imbalance of coagulation and fibrinolysis in favor of 
      coagulation and the impairment of the adhesive molecule pathway in RA. This 
      action of TNF-alpha and IL-6 does not seem to be countered by the 
      antiinflammatory cytokine IL-1O action.
FAU - Kamper, E F
AU  - Kamper EF
AD  - Department of Experimental Physiology, Medical School, University of Athens, 
      Greece. ekamper@cc.uoa.gr
FAU - Kopeikina, L T
AU  - Kopeikina LT
FAU - Trontzas, P
AU  - Trontzas P
FAU - Potamianou, A
AU  - Potamianou A
FAU - Tsiroglou, E
AU  - Tsiroglou E
FAU - Stavridis, J C
AU  - Stavridis JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Interleukin-6)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 130068-27-8 (Interleukin-10)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Aged
MH  - Arthritis, Rheumatoid/blood/*physiopathology
MH  - Female
MH  - *Fibrinolysis
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Interleukin-10/*physiology
MH  - Interleukin-6/*physiology
MH  - Male
MH  - Middle Aged
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - Reference Values
MH  - Severity of Illness Index
MH  - Tissue Plasminogen Activator/blood
MH  - Tumor Necrosis Factor-alpha/*physiology
EDAT- 2000/11/28 11:00
MHDA- 2001/04/03 10:01
CRDT- 2000/11/28 11:00
PHST- 2000/11/28 11:00 [pubmed]
PHST- 2001/04/03 10:01 [medline]
PHST- 2000/11/28 11:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 2000 Nov;27(11):2545-50.