PMID- 11094437
OWN - NLM
STAT- MEDLINE
DCOM- 20010412
LR  - 20181113
IS  - 1465-9905 (Print)
IS  - 1465-9913 (Electronic)
IS  - 1465-9905 (Linking)
VI  - 2
IP  - 4
DP  - 2000
TI  - What you should know about PR3-ANCA. Structural aspects of antibodies to 
      proteinase 3 (PR3).
PG  - 255-9
AB  - Reactive antigenic epitopes on presumed autoantigens of biologic interest have 
      been examined by many researchers. The central third complementarity-determining 
      region (CDR3) residues of a human monoclonal anti-proteinase 3 (PR3) antibody 
      contained many negatively charged aspartic acid residues, perhaps contributing to 
      its reactivity with positively charged PR3 regions. Examination of four other 
      human monoclonal anti-PR3 antibodies shows a number of negatively charged 
      residues within their CDR3 regions. Mapping of segments of linear PR3-epitopes 
      reacting with anti-neutrophil cytoplasmic antibodies (ANCA) demonstrated a 
      preliminary estimate of structures contributing to antigenic determinants. T-cell 
      epitopes on PR3 are reported in studies of chronic myeloid leukemia. These T-cell 
      epitopes appear to be human leukocyte antigen (HLA) A2.1 restricted.
FAU - Peen, E
AU  - Peen E
AD  - Department of Medicine, University of Bergen, Haukeland Hospital, Bergen, Norway. 
      elisabeth.peen@medb.uib.no
FAU - Williams, R C Jr
AU  - Williams RC Jr
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20000612
PL  - England
TA  - Arthritis Res
JT  - Arthritis research
JID - 100913255
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Epitopes)
RN  - 0 (Recombinant Proteins)
RN  - EC 3.4.21.- (Serine Endopeptidases)
RN  - EC 3.4.21.76 (Myeloblastin)
SB  - IM
MH  - Animals
MH  - Antibodies, Antineutrophil Cytoplasmic/*immunology
MH  - Epitopes/immunology
MH  - Humans
MH  - Myeloblastin
MH  - Recombinant Proteins/immunology
MH  - Serine Endopeptidases/*immunology
MH  - T-Lymphocytes/immunology
PMC - PMC130014
EDAT- 2000/11/30 11:00
MHDA- 2001/04/17 10:01
PMCR- 2000/06/12
CRDT- 2000/11/30 11:00
PHST- 1999/12/21 00:00 [received]
PHST- 2000/02/24 00:00 [revised]
PHST- 2000/03/07 00:00 [accepted]
PHST- 2000/11/30 11:00 [pubmed]
PHST- 2001/04/17 10:01 [medline]
PHST- 2000/11/30 11:00 [entrez]
PHST- 2000/06/12 00:00 [pmc-release]
AID - ar97 [pii]
AID - 10.1186/ar97 [doi]
PST - ppublish
SO  - Arthritis Res. 2000;2(4):255-9. doi: 10.1186/ar97. Epub 2000 Jun 12.