PMID- 11095094
OWN - NLM
STAT- MEDLINE
DCOM- 20010531
LR  - 20080815
IS  - 1121-760X (Print)
IS  - 1121-760X (Linking)
VI  - 44
IP  - 3
DP  - 2000
TI  - Apoptosis and systemic autoimmunity: the dendritic cell connection.
PG  - 229-36
AB  - Much effort has been devoted in recent years to the events linking recognition 
      and disposal of apoptotic cells to sustained immunity towards the antigens they 
      contain. Programmed death via apoptosis indeed provides most of the raw material 
      the immune system exploits to establish self tolerance, i.e. to learn how to 
      distinguish between self constituents and foreign antigens, belonging to invading 
      pathogens. In parallel, events occurring during cell death may enable a 
      restricted array of molecules endowed with diverse structure, function and 
      intracellular distribution to satisfy the requirement to evoke and maintain 
      autoimmune responses. Dendritic cells (DCs), the most potent antigen presenting 
      cells, appear to play a crucial role. Here we will discuss some of the constrains 
      regulating the access of dying cells' antigens to DCs, as well as censorship 
      mechanisms that prevent their maturation and the full explication of their 
      antigen presenting function.
FAU - Rovere, P
AU  - Rovere P
AD  - Cancer Immunotherapy and Gene Therapy Program and Immunopathology Unit, 
      Department of Pathology and Molecular Medicine, Istituto Scientifico H S. 
      Raffaele, Milano, Italy. p.rovere@hsr.it
FAU - Fazzini, F
AU  - Fazzini F
FAU - Sabbadini, M G
AU  - Sabbadini MG
FAU - Manfredi, A A
AU  - Manfredi AA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Eur J Histochem
JT  - European journal of histochemistry : EJH
JID - 9207930
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Autoantibodies/immunology
MH  - Autoimmune Diseases/immunology
MH  - Autoimmunity/*physiology
MH  - Dendritic Cells/*immunology
MH  - Humans
RF  - 47
EDAT- 2000/11/30 11:00
MHDA- 2001/06/02 10:01
CRDT- 2000/11/30 11:00
PHST- 2000/11/30 11:00 [pubmed]
PHST- 2001/06/02 10:01 [medline]
PHST- 2000/11/30 11:00 [entrez]
PST - ppublish
SO  - Eur J Histochem. 2000;44(3):229-36.