PMID- 11095127
OWN - NLM
STAT- MEDLINE
DCOM- 20010301
LR  - 20131121
IS  - 1082-3069 (Print)
IS  - 1082-3069 (Linking)
VI  - 31
IP  - 6
DP  - 2000 Nov-Dec
TI  - A case of insulin dependent diabetes mellitus following systemic treatment for 
      Vogt-Koyanagi-Harada syndrome.
PG  - 487-90
AB  - A 29-year-old man developed acute visual impairment, cough, and headache. Both 
      eyes showed serous retinal detachment in the posterior fundus. Fluorescein 
      angiography showed subretinal pooling of fluorescein in the late phase. A 
      diagnosis of Vogt-Koyanagi-Harada (VKH) syndrome was made based on clinical 
      features. Treatment with systemic corticosteroids resulted in improvement of 
      uveitis and both eyes showed "sunset glow" fundus 11 months later. 
      Insulin-dependent diabetes mellitus (IDDM) developed 13 months later (3 months 
      after systemic corticosteroid therapy). Despite treatment with insulin, glycemic 
      control was poor. Human leukocyte antigen (HLA) typing showed HLADR9 and DQB 
      1*0303 related to IDDM. We postulated that treatment with corticosteroids 
      precipitated IDDM, a yet unknown common autoimmune mechanism might have caused 
      IDDM and VKH, or both conditions occurred coincidentally.
FAU - Maruyama, Y
AU  - Maruyama Y
AD  - Department of Ophthalmology, Hamamatsu Medical Center, Japan.
FAU - Hayashi, H
AU  - Hayashi H
FAU - Takahashi, K
AU  - Takahashi K
FAU - Iino, K
AU  - Iino K
FAU - Kora, Y
AU  - Kora Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Ophthalmic Surg Lasers
JT  - Ophthalmic surgery and lasers
JID - 9517132
RN  - 0 (Blood Glucose)
RN  - 0 (Glucocorticoids)
RN  - 0 (HLA Antigens)
RN  - 0 (Insulin)
RN  - 9842X06Q6M (Betamethasone)
SB  - IM
MH  - Adult
MH  - Betamethasone/*adverse effects
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 1/blood/*chemically induced/immunology
MH  - Fluorescein Angiography
MH  - Fundus Oculi
MH  - Glucocorticoids/*adverse effects
MH  - HLA Antigens/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Insulin/metabolism
MH  - Male
MH  - Prognosis
MH  - Uveomeningoencephalitic Syndrome/diagnosis/*drug therapy/immunology
EDAT- 2000/11/30 11:00
MHDA- 2001/03/07 10:01
CRDT- 2000/11/30 11:00
PHST- 2000/11/30 11:00 [pubmed]
PHST- 2001/03/07 10:01 [medline]
PHST- 2000/11/30 11:00 [entrez]
PST - ppublish
SO  - Ophthalmic Surg Lasers. 2000 Nov-Dec;31(6):487-90.