PMID- 11095971
OWN - NLM
STAT- MEDLINE
DCOM- 20010104
LR  - 20131121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 278
IP  - 3
DP  - 2000 Nov 30
TI  - Additivity of the proliferative effects of HGF/SF and EGF on hepatocytes.
PG  - 698-703
AB  - The additivity of DNA synthesis induced by hepatocyte growth factor/scatter 
      factor (HGF/SF) and epidermal growth factor (EGF) was revealed in periportal 
      hepatocytes (PPH), perivenous hepatocytes (PVH), and primary hepatocytes. 
      Furthermore, additivity of the signal transduction pathway of HGF/SF and EGF was 
      investigated (i.e., the activity of mitogen-activated protein kinase (MAPK) 
      induced by HGF/SF and EGF), but it was not seen in PPH, PVH, or primary 
      hepatocytes, although wortomannin, a PI 3-kinase inhibitor, abolished the 
      additivity. The additivity of DNA synthesis induced by HGF/SF and EGF was not 
      related to hepatocyte heterogeneity, but to a difference in the signal 
      transduction pathway, probably another pathway that is different from the 
      classical MAPK (MAPK/ERK1,2) path.
CI  - Copyright 2000 Academic Press.
FAU - Fukujin, H
AU  - Fukujin H
AD  - Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo, 
      Japan.
FAU - Fujita, T
AU  - Fujita T
FAU - Mine, T
AU  - Mine T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 9007-49-2 (DNA)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Animals
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - DNA/biosynthesis
MH  - Epidermal Growth Factor/*pharmacology
MH  - Hepatocyte Growth Factor/*pharmacology
MH  - Hepatocytes/cytology/*drug effects/physiology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Signal Transduction/drug effects/physiology
MH  - Thymidine/metabolism
EDAT- 2000/11/30 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/30 11:00
PHST- 2000/11/30 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/30 11:00 [entrez]
AID - S0006-291X(00)93863-4 [pii]
AID - 10.1006/bbrc.2000.3863 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2000 Nov 30;278(3):698-703. doi: 
      10.1006/bbrc.2000.3863.