PMID- 11095999
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20191210
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 31
IP  - 6
DP  - 2000 Dec
TI  - Relationship between interleukin-6 plasma concentration in patients with sepsis, 
      monocyte phenotype, monocyte phagocytic properties, and cytokine production.
PG  - 1338-42
AB  - Monocyte phenotype, their phagocytic capacity as well as the cytokine production 
      from 10 patients with sepsis with low interleukin-6 (IL-6) serum concentrations 
      (<1000 pg/mL) and 8 patients with sepsis with high IL-6 (> or = 1000 pg/mL) 
      plasma concentrations were investigated within 24 hours of fulfilling the 
      criteria for sepsis. Monocytes from patients with high IL-6 levels had higher 
      levels of human leukocyte antigen (HLA)-DR, HLA-ABC, CD64, and CD71, and the 
      production of tumor necrosis factor-alpha (TNF-alpha) and IL-8, as well as the 
      capacity of monocytes to phagocytose, was significantly elevated. Of 8 patients 
      with high levels of plasma IL-6, 4 patients died. In contrast, all 10 patients 
      with low plasma IL-6 concentrations survived until day 28. Patients who died had 
      constant high IL-6 concentrations during the first 3 days, whereas IL-6 levels in 
      patients who survived decreased by 88%. Our data indicate that IL-6 levels are a 
      better prognostic parameter in the early phase of sepsis than the monocyte HLA-DR 
      expression.
FAU - Spittler, A
AU  - Spittler A
AD  - Department of Surgery, Research Laboratories, University of Vienna, Vienna, 
      Austria. a.spittler@akh-wien.ac.at
FAU - Razenberger, M
AU  - Razenberger M
FAU - Kupper, H
AU  - Kupper H
FAU - Kaul, M
AU  - Kaul M
FAU - Hackl, W
AU  - Hackl W
FAU - Boltz-Nitulescu, G
AU  - Boltz-Nitulescu G
FAU - Fugger, R
AU  - Fugger R
FAU - Roth, E
AU  - Roth E
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20001122
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Cytokines)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Cytokines/*biosynthesis
MH  - Female
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - HLA-DR Antigens/metabolism
MH  - Humans
MH  - Immunophenotyping
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Monocytes/classification/*immunology/metabolism
MH  - Phagocytosis/*immunology
MH  - Prognosis
MH  - Sepsis/*immunology
EDAT- 2000/11/30 11:00
MHDA- 2001/05/01 10:01
CRDT- 2000/11/30 11:00
PHST- 1999/11/12 00:00 [received]
PHST- 2000/04/24 00:00 [revised]
PHST- 2000/11/30 11:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2000/11/30 11:00 [entrez]
AID - CID994274 [pii]
AID - 10.1086/317499 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2000 Dec;31(6):1338-42. doi: 10.1086/317499. Epub 2000 Nov 22.