PMID- 11096509
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1092-8464 (Print)
IS  - 1092-8464 (Linking)
VI  - 2
IP  - 1
DP  - 2000 Feb
TI  - Unstable Angina.
PG  - 37-54
AB  - The recent availability of novel antiplatelet and antithrombin agents has 
      revolutionized the therapeutic options for intermediate- and high-risk unstable 
      angina (UA). Current guidelines recommend aspirin, unfractionated heparin (UFH), 
      and antianginal therapy. Low-molecular-weight heparin (LMWH) and direct thrombin 
      inhibitors have significant theoretical advantages and apparent clinical benefits 
      compared with UFH and are good alternatives in selected patients. Glycoprotein 
      (GP) IIb/IIIa receptor inhibition reduces the future risk of myocardial 
      infarction (MI) and may reduce the incidence of death in patients with unstable 
      angina. In particular, these drugs should be considered for use in combination 
      with aspirin and UFH in patients undergoing an "early invasive" approach. 
      Coronary revascularization plays an important role in high-risk patients and in 
      those with refractory angina, but its routine application continues to be 
      controversial. Issues regarding the use of LMWH in combination with GP IIb/IIIa 
      inhibitors and during percutaneous transluminal coronary angioplasty (PTCA) are 
      being addressed in clinical trials. Ideally, the incidence of serious cardiac 
      events in patients with UA will continue to decrease with the ongoing search for 
      potent drug combinations that achieve early control of intracoronary thrombosis.
FAU - Murad, MB
AU  - Murad MB
AD  - Division of Cardiovascular Medicine, Hennepin County Medical Center, 701 Park 
      Avenue South, Minneapolis, MN 55415, USA.
FAU - Henry, TD
AU  - Henry TD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Treat Options Cardiovasc Med
JT  - Current treatment options in cardiovascular medicine
JID - 9815942
EDAT- 2000/11/30 00:00
MHDA- 2000/11/30 00:01
CRDT- 2000/11/30 00:00
PHST- 2000/11/30 00:00 [pubmed]
PHST- 2000/11/30 00:01 [medline]
PHST- 2000/11/30 00:00 [entrez]
AID - 10.1007/s11936-000-0027-9 [doi]
PST - ppublish
SO  - Curr Treat Options Cardiovasc Med. 2000 Feb;2(1):37-54. doi: 
      10.1007/s11936-000-0027-9.