PMID- 11097079
OWN - NLM
STAT- MEDLINE
DCOM- 20010222
LR  - 20191210
IS  - 0033-2917 (Print)
IS  - 0033-2917 (Linking)
VI  - 30
IP  - 6
DP  - 2000 Nov
TI  - Validation of the prospective NIMH-Life-Chart Method (NIMH-LCM-p) for 
      longitudinal assessment of bipolar illness.
PG  - 1391-7
AB  - BACKGROUND: Systematic and accurate depiction of a patient's course of illness is 
      crucial for assessing the efficacy of maintenance treatments for bipolar 
      disorder. This need to rate the long-term prospective course of illness led to 
      the development of the National Institute of Mental Health prospective Life Chart 
      Methodology (NIMH-LCM-p or LCM). The NIMH-LCM-p allows for the daily assessment 
      of mood and episode severity based on the degree of mood associated functional 
      impairment. We have previously presented preliminary evidence of the reliability 
      and validity of the LCM, and its utility in clinical trials. This study is a 
      further and more extensive validation of the clinician rated NIMH-LCM-p. METHODS: 
      Subjects included 270 bipolar patients from the five sites participating in the 
      Stanley Foundation Bipolar Network. Daily prospective LCM ratings on the 
      clinician form were initiated upon entry, in addition to at least monthly ratings 
      with the Inventory of Depressive Symptomatology-clinician rated (IDS-C), the 
      Young Mania Rating Scale (YMRS) and the Global Assessment of Functioning (GAF). 
      We correlated appropriate measures and time domains of the LCM with the IDS-C, 
      YMRS and GAF. RESULTS: Severity of depression on the LCM and on the IDS-C were 
      highly correlated in 270 patients (r = -0.785, P < 0.001). Similarly, a strong 
      correlation was found between LCM mania and the YMRS (r = 0.656, P < 0.001) and 
      between the LCM average severity of illness and the GAF (r = -0.732, P < 0.001). 
      CONCLUSIONS: These data further demonstrate the validity and potential utility of 
      the NIMH-LCM-p for the detailed daily longitudinal assessment of manic and 
      depressive severity and course, and response to treatment.
FAU - Denicoff, K D
AU  - Denicoff KD
AD  - Biological Psychiatry Branch, NIMH, NIH and Stanley Foundation Bipolar Network, 
      NAMI Research Institute, Bethesda, MD 20892-1272, USA.
FAU - Leverich, G S
AU  - Leverich GS
FAU - Nolen, W A
AU  - Nolen WA
FAU - Rush, A J
AU  - Rush AJ
FAU - McElroy, S L
AU  - McElroy SL
FAU - Keck, P E
AU  - Keck PE
FAU - Suppes, T
AU  - Suppes T
FAU - Altshuler, L L
AU  - Altshuler LL
FAU - Kupka, R
AU  - Kupka R
FAU - Frye, M A
AU  - Frye MA
FAU - Hatef, J
AU  - Hatef J
FAU - Brotman, M A
AU  - Brotman MA
FAU - Post, R M
AU  - Post RM
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*diagnosis/*psychology
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Netherlands
MH  - *Outpatients
MH  - Psychiatric Status Rating Scales/*standards
MH  - Psychometrics
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Survival Analysis
MH  - United States
EDAT- 2000/11/30 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/11/30 11:00
PHST- 2000/11/30 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/11/30 11:00 [entrez]
AID - 10.1017/s0033291799002810 [doi]
PST - ppublish
SO  - Psychol Med. 2000 Nov;30(6):1391-7. doi: 10.1017/s0033291799002810.