PMID- 11099146
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20190716
IS  - 0001-6489 (Print)
IS  - 0001-6489 (Linking)
VI  - 120
IP  - 6
DP  - 2000 Sep
TI  - Distribution of HLA-A, -B and -DRB1 alleles in patients with sudden sensorineural 
      hearing loss.
PG  - 710-5
AB  - This study was performed to investigate the association between human leukocyte 
      antigen (HLA) and susceptibility to sudden sensorineural hearing loss in the 
      Korean population. HLA-A and HLA-B typing using a standard 
      microlymphocytotoxicity technique and HLA-DRB1 genotyping were performed in 35 
      patients with sudden sensorineural hearing loss and in 206 healthy controls. 
      Prednisone (usual dose 60 mg/day) was administered for 6 days and tapered for an 
      additional 4-6 days. Both initial hearing levels at the onset of deafness and 
      final hearing levels after treatment were examined and evaluated for association 
      with HLA alleles. The frequency of HLA-DRB1*14 was increased in patients with 
      sudden sensorineural hearing loss compared with controls (relative risk [RR] = 
      2.7, p = 0.016). The frequencies of HLA-A2, -A31, -B52, -B61, -DRB1*04, -DRB1*11 
      and -DRB1*12 were slightly higher than in the controls, but did not reach 
      statistical significance. When an association between the treatment results and 
      HLA alleles was also evaluated, the frequency of HLA-DRB1*04 was found to be 
      increased in the patients who did not respond to steroid treatment compared with 
      both patients who responded well to steroid (50%, vs 16%, p = 0.034) and controls 
      (RR = 3.0, p = 0.046). These results suggest that there is an association between 
      HLA-DRB1*14 and disease susceptibility and that the presence of HLA-DRB1*04 may 
      be an useful marker for predicting a poor prognosis in Korean patients with 
      sudden sensorineural hearing loss.
FAU - Yeo, S W
AU  - Yeo SW
AD  - Department of Otolaryngology, Kangnam St. Mary's Hospital, The Catholic 
      University of Korea, College of Medicine, Seoul, South Korea. swyeo@cmc.cuk.ac.kr
FAU - Chang, K H
AU  - Chang KH
FAU - Suh, B D
AU  - Suh BD
FAU - Kim, T G
AU  - Kim TG
FAU - Han, H
AU  - Han H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Inflammatory Agents/administration & dosage/therapeutic use
MH  - Audiometry, Pure-Tone/methods
MH  - Female
MH  - Gene Frequency/*genetics/*immunology
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-A Antigens/*genetics/*immunology
MH  - HLA-B Antigens/*genetics/*immunology
MH  - HLA-DR Antigens/*genetics/*immunology
MH  - HLA-DRB1 Chains
MH  - *Hearing Loss, Sudden/diagnosis/drug therapy/ethnology/genetics/immunology
MH  - Humans
MH  - Korea/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prednisone/administration & dosage/therapeutic use
MH  - Recovery of Function
MH  - Severity of Illness Index
EDAT- 2000/12/01 11:00
MHDA- 2001/08/10 10:01
CRDT- 2000/12/01 11:00
PHST- 2000/12/01 11:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2000/12/01 11:00 [entrez]
AID - 10.1080/000164800750000225 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2000 Sep;120(6):710-5. doi: 10.1080/000164800750000225.