PMID- 11099195
OWN - NLM
STAT- MEDLINE
DCOM- 20010315
LR  - 20170214
IS  - 0094-2405 (Print)
IS  - 0094-2405 (Linking)
VI  - 27
IP  - 10
DP  - 2000 Oct
TI  - A dose-volume histogram based optimization algorithm for ultrasound guided 
      prostate implants.
PG  - 2286-92
AB  - The task of treatment planning for prostate implants is to find an optimal seed 
      configuration, comprising the target coverage and dosimetric consideration of 
      critical structures such as the rectum and urethra. An efficient method to 
      accomplish this is to use an inverse planning technique that derives the 
      optimized solution from a prescribed treatment goal. The goal can be specified in 
      the voxel domain as the desired doses to the voxels of the target and critical 
      structures, or in the dose volume representation as the desired dose volume 
      histograms (DVHs) of the target and critical structures. The DVH based 
      optimization has been successfully used in plan optimization for 
      intensity-modulated radiation therapy (IMRT) but little attention has been paid 
      to its application in prostate implants. Clinically, it has long been known that 
      some normal structure tolerances are more accurately assessed by volumetric 
      information. Dose-volume histograms are also widely used for plan evaluation. 
      When working in the DVH domain for optimization one has more control over the 
      final DVHs. We have constructed an objective function sensitive to the DVHs of 
      the target and critical structures. The objective function is minimized using an 
      iterative algorithm, starting from a randomly selected initial seed 
      configuration. At each iteration step, a trial position is given to a randomly 
      selected source and the trial position is accepted if the objective function is 
      decreased. To avoid being trapped in a less optimal local minimum, the 
      optimization process is repeated. The final plan is selected from a pool of 
      optimized plans obtained from a series of randomized initial seed configurations.
FAU - Chen, Y
AU  - Chen Y
AD  - Department of Radiation Oncology, Stanford University School of Medicine, 
      California 94305, USA. yan.chen@mail.tju.edu
FAU - Boyer, A L
AU  - Boyer AL
FAU - Xing, L
AU  - Xing L
LA  - eng
GR  - CA 43840/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
SB  - IM
MH  - *Algorithms
MH  - Brachytherapy/*methods/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Prostatic Neoplasms/diagnostic imaging/*radiotherapy
MH  - Radiotherapy Planning, Computer-Assisted/*methods/statistics & numerical data
MH  - Ultrasonography
EDAT- 2000/12/01 11:00
MHDA- 2001/03/17 10:01
CRDT- 2000/12/01 11:00
PHST- 2000/12/01 11:00 [pubmed]
PHST- 2001/03/17 10:01 [medline]
PHST- 2000/12/01 11:00 [entrez]
AID - 10.1118/1.1308087 [doi]
PST - ppublish
SO  - Med Phys. 2000 Oct;27(10):2286-92. doi: 10.1118/1.1308087.