PMID- 11099989
OWN - NLM
STAT- MEDLINE
DCOM- 20010104
LR  - 20161124
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 140
IP  - 6
DP  - 2000 Dec
TI  - A pilot experience with permanent biventricular pacing to treat advanced heart 
      failure.
PG  - 862-70
AB  - BACKGROUND: The prognosis and quality of life of patients with advanced heart 
      failure remain poor. The purpose of this study was to evaluate new 
      nonpharmacologic approaches. Biventricular pacing was proposed in this 
      indication, based on the encouraging results of acute hemodynamics studies. 
      METHODS: Fifty patients with drug-resistant heart failure (New York Heart 
      Association [NYHA] class III/IV, 16 of 34) were consecutively implanted with 
      biventricular pacemakers. All patients had severe dilated cardiomyopathy and 
      intraventricular conduction delay. Survival, NYHA class, electrocardiogram, 
      echocardiographic data, and exercise tolerance were assessed over a mean 
      follow-up period of 15.4 +/- 10. 2 months. RESULTS: At the end of follow-up, 55% 
      of patients were alive without heart transplantation or left ventricular 
      assistance device. The mortality rate was significantly lower in class III (12. 
      5%) than in class IV patients (52.5%). In survivors, biventricular pacing 
      significantly improved symptoms (NYHA class 2.2 +/- 0.5 at follow-up vs 3.7 +/- 
      0.5 at baseline) and exercise tolerance ((. )VO(2) peak 15.5 +/- 3.4 mL/min per 
      kilogram at follow-up vs 11.1 +/- 3 mL/min per kilogram at baseline). 
      CONCLUSIONS: Biventricular pacing appears to improve the functional status of 
      patients with dilated cardiomyopathy with advanced heart failure. The technique 
      appears to be attractive as an additive treatment, especially in class III 
      patients. Controlled randomized studies are needed to validate this novel 
      concept.
FAU - Leclercq, C
AU  - Leclercq C
AD  - Departement de Cardiologie et Maladies Vasculaires, Centre Cardio-Pneumologique, 
      Rennes Cedex, France. christophe.leclercq@chu-rennes.fr
FAU - Cazeau, S
AU  - Cazeau S
FAU - Ritter, P
AU  - Ritter P
FAU - Alonso, C
AU  - Alonso C
FAU - Gras, D
AU  - Gras D
FAU - Mabo, P
AU  - Mabo P
FAU - Lazarus, A
AU  - Lazarus A
FAU - Daubert, J C
AU  - Daubert JC
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
CIN - Am Heart J. 2000 Dec;140(6):821-3. PMID: 11099982
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cardiac Pacing, Artificial/methods
MH  - Death, Sudden, Cardiac/prevention & control
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Heart Failure/mortality/physiopathology/*therapy
MH  - Heart Transplantation/mortality
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/physiology
MH  - Pilot Projects
MH  - Prognosis
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Survival Rate
MH  - United States/epidemiology
MH  - Ventricular Function, Left/physiology
EDAT- 2000/12/02 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/02 11:00
PHST- 2000/12/02 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/02 11:00 [entrez]
AID - S0002-8703(00)28407-X [pii]
AID - 10.1067/mhj.2000.110570 [doi]
PST - ppublish
SO  - Am Heart J. 2000 Dec;140(6):862-70. doi: 10.1067/mhj.2000.110570.