PMID- 11100912
OWN - NLM
STAT- MEDLINE
DCOM- 20010614
LR  - 20081121
IS  - 1090-9508 (Print)
IS  - 1090-9508 (Linking)
VI  - 3
IP  - 6
DP  - 2000 Nov-Dec
TI  - Perinatally cotransmitted human herpesvirus 6 is activated in children born with 
      human immunodeficiency virus infection.
PG  - 317-23
AB  - OBJECTIVE: To evaluate the mother-to-child transmission profile of human 
      immunodeficiency virus (HIV) as well as human herpesvirus 6 (HHV-6) and to 
      examine active replication of HHV-6 in the HIV-infected mothers and their 
      newborns. STUDY DESIGN/METHODS: This polymerase chain reaction (PCR)-based 
      detection was done using DNA from peripheral blood mononuclear cells (PBMCs) and 
      milk cells from the mothers, PBMC from the newborns, and DNA derived from plasma 
      and cell-free milk fluid from mothers and plasma of the newborns. None of the 
      mothers received antiretroviral treatment. RESULTS: HIV was transmitted to 50% 
      newborns and, of 36 total mothers, 8 had actively replicating HHV-6 detectable in 
      their plasma and 2 also had it in the lactosera. Among the neonates. HHV-6 was 
      found in the PBMC DNA of seven and in the plasma fractions of five, the latter 
      five newborns were all HIV-infected at birth. CONCLUSION: Perinatally 
      cotransmitted HHV-6 was always activated in the neonates who were born with HIV 
      infection. Also, HHV-6 can be detected in the milk cells and the activated virus 
      may be present in the lactosera of some of these HlV-infected mothers.
FAU - Joshi, P J
AU  - Joshi PJ
AD  - Virology Laboratory, Cancer Research Institute, Tata Memorial Centre, Parel, 
      Mumbai, India.
FAU - Merchant, R H
AU  - Merchant RH
FAU - Pokharankar, S L
AU  - Pokharankar SL
FAU - Damania, K S
AU  - Damania KS
FAU - Gilada, I S
AU  - Gilada IS
FAU - Mukhopadhyaya, R
AU  - Mukhopadhyaya R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Hum Virol
JT  - Journal of human virology
JID - 9805755
RN  - 0 (DNA, Viral)
SB  - IM
MH  - DNA, Viral/blood
MH  - Female
MH  - HIV Infections/complications/*transmission/virology
MH  - HIV-1/genetics/isolation & purification/physiology
MH  - HIV-2/genetics/isolation & purification/physiology
MH  - Herpesviridae Infections/complications/*transmission/virology
MH  - Herpesvirus 6, Human/genetics/*growth & development/isolation & purification
MH  - Humans
MH  - Infant, Newborn
MH  - *Infectious Disease Transmission, Vertical
MH  - Milk, Human/virology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/virology
MH  - Virus Activation
MH  - Virus Replication
EDAT- 2000/01/11 19:15
MHDA- 2001/06/23 10:01
CRDT- 2000/01/11 19:15
PHST- 2000/01/11 19:15 [pubmed]
PHST- 2001/06/23 10:01 [medline]
PHST- 2000/01/11 19:15 [entrez]
PST - ppublish
SO  - J Hum Virol. 2000 Nov-Dec;3(6):317-23.