PMID- 11102274
OWN - NLM
STAT- MEDLINE
DCOM- 20010118
LR  - 20091103
VI  - 13
IP  - 4
DP  - 2000 Dec
TI  - The HLA system in blood transfusion.
PG  - 511-32
AB  - The human leukocyte antigen (HLA) system, originally discovered as the result of 
      a transfusion reaction, is now known to play a crucial role in many areas of 
      clinical medicine. The main function of the HLA molecules is to present antigenic 
      peptides to the immune system and in this way regulate the induction of immune 
      responses. This is a highly regulated process which requires a close interaction 
      between the HLA molecules, the antigenic peptide and the T cell receptor.HLA 
      molecules are also known to be associated with a variety of autoimmune, 
      non-autoimmune and infectious diseases and to restrict the antibody response to 
      certain antigens and to vaccines. It is likely that the mechanism responsible for 
      this restriction is the preferential presentation of antigen-derived peptides to 
      T cells. Furthermore, HLA antigens, in contrast to most polymorphic molecules, 
      have the ability to activate the immune system using two different pathways of T 
      cell activation, the direct and indirect pathways. As a result of these features, 
      HLA antigens and antibodies are responsible for some of the serious clinical 
      complications of blood transfusion, and have an important influence on the 
      outcome of solid organ and haemopoietic stem cell transplantation.
CI  - Copyright 2000 Harcourt Publishers Ltd.
FAU - Navarrete, C V
AU  - Navarrete CV
AD  - Department of Histocompatibility & Immunogenetics, National Blood Service, North 
      London Centre, London, NW9 5BG, UK.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Baillieres Best Pract Res Clin Haematol
JT  - Bailliere's best practice & research. Clinical haematology
JID - 100900679
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - *Blood Group Incompatibility
MH  - *Blood Transfusion
MH  - Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - *HLA Antigens/genetics/immunology
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Isoantibodies/blood
MH  - Organ Transplantation
MH  - Polymorphism, Genetic
MH  - Transplantation Immunology
RF  - 84
EDAT- 2000/12/05 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/05 11:00
PHST- 2000/12/05 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/05 11:00 [entrez]
AID - S1521692600900975 [pii]
AID - 10.1053/beha.2000.0097 [doi]
PST - ppublish
SO  - Baillieres Best Pract Res Clin Haematol. 2000 Dec;13(4):511-32. doi: 
      10.1053/beha.2000.0097.