PMID- 11103878 OWN - NLM STAT- MEDLINE DCOM- 20001214 LR - 20191104 IS - 0955-8810 (Print) IS - 0955-8810 (Linking) VI - 11 IP - 3-4 DP - 2000 Jun TI - Studies in animal models and humans suggesting a role of nerve growth factor in schizophrenia-like disorders. PG - 235-42 AB - Neurotrophic factors, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), are known to play a crucial role in growth, differentiation and function in a variety of brain neurons during development and in adult life. We have recently shown that environmental changes, aggressive behavior and anxiety-like responses alter both circulating and brain basal NGF levels. In the present review, we present data obtained using animal models which suggest that neurotrophic factors, particularly NGF and BDNF, might be implicated in mechanism(s) leading to a condition associated with schizophrenic-like behaviors. The hypothesis that neurotrophins of the NGF family can be implicated in some maldevelopmental aspects of schizophrenia is supported by findings indicating that the constitutive levels of NGF and BDNF are affected in schizophrenic patients. FAU - Aloe, L AU - Aloe L AD - Institute of Neurobiology, CNR, Rome, Italy. aloe@in.rm.cnr.it FAU - Iannitelli, A AU - Iannitelli A FAU - Angelucci, F AU - Angelucci F FAU - Bersani, G AU - Bersani G FAU - Fiore, M AU - Fiore M LA - eng PT - Journal Article PT - Review PL - England TA - Behav Pharmacol JT - Behavioural pharmacology JID - 9013016 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Central Nervous System Depressants) RN - 3K9958V90M (Ethanol) RN - 9061-61-4 (Nerve Growth Factor) SB - IM MH - Aggression MH - Animals MH - Anxiety/drug therapy MH - Brain/growth & development/pathology MH - Brain-Derived Neurotrophic Factor/*pharmacology MH - Central Nervous System Depressants/adverse effects MH - Disease Models, Animal MH - Ethanol/adverse effects MH - Humans MH - Nerve Growth Factor/*pharmacology MH - Rats MH - Schizophrenia/*physiopathology RF - 106 EDAT- 2000/12/05 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/12/05 11:00 PHST- 2000/12/05 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/12/05 11:00 [entrez] AID - 10.1097/00008877-200006000-00007 [doi] PST - ppublish SO - Behav Pharmacol. 2000 Jun;11(3-4):235-42. doi: 10.1097/00008877-200006000-00007.