PMID- 11103939
OWN - NLM
STAT- MEDLINE
DCOM- 20010125
LR  - 20201120
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 19
IP  - 47
DP  - 2000 Nov 9
TI  - Synchronous and regulated expression of two AU-binding proteins, AUF1 and HuR, 
      throughout murine development.
PG  - 5377-84
AB  - The AUF1 (hnRNPD) and HuR (ELAV-like) proteins, potential trans-acting factors 
      for regulated mRNA decay, bind in vitro to A+U-rich elements (AREs) found in the 
      3' untranslated region (3' UTR) of many labile transcripts. In an effort to 
      determine whether these trans-acting factors are likely to play a role in 
      embryogenesis, we have analysed their expression during mouse development both at 
      the mRNA and protein levels. We show that AUF1 and HuR are expressed at all the 
      developmental stages analysed from day 8.5 of embryonic development to adulthood. 
      Expression levels are dynamic, varying between tissues and developmental stages. 
      However, a strong positive correlation between AUF1 and HuR protein levels was 
      observed in all examined tissues. Finally, we compared AUF1 and HuR expression 
      with accumulation of one common target mRNA, c-myc. The similar spatio-temporal 
      distribution of these proteins and of c-myc mRNA is in agreement with a potential 
      concerted role in ARE-mediated control of mRNA stability.
FAU - Gouble, A
AU  - Gouble A
AD  - Centre de Biologie du Developpement, CNRS-UMR5547, Universite Paul Sabatier, 
      Toulouse, France.
FAU - Morello, D
AU  - Morello D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Antigens, Surface)
RN  - 0 (ELAV Proteins)
RN  - 0 (ELAV-Like Protein 1)
RN  - 0 (ELAVL1 protein, human)
RN  - 0 (HNRNPD protein, human)
RN  - 0 (Heterogeneous Nuclear Ribonucleoprotein D0)
RN  - 0 (Heterogeneous-Nuclear Ribonucleoprotein D)
RN  - 0 (Hnrpd protein, mouse)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (RNA-Binding Proteins)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Animals
MH  - *Antigens, Surface
MH  - ELAV Proteins
MH  - ELAV-Like Protein 1
MH  - Embryonic and Fetal Development
MH  - Female
MH  - *Gene Expression Regulation, Developmental
MH  - Heterogeneous Nuclear Ribonucleoprotein D0
MH  - *Heterogeneous-Nuclear Ribonucleoprotein D
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Proto-Oncogene Proteins c-myc/genetics/metabolism
MH  - RNA/biosynthesis
MH  - RNA Stability
MH  - RNA-Binding Proteins/biosynthesis/*genetics
EDAT- 2000/12/05 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/05 11:00
PHST- 2000/12/05 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/05 11:00 [entrez]
AID - 10.1038/sj.onc.1203910 [doi]
PST - ppublish
SO  - Oncogene. 2000 Nov 9;19(47):5377-84. doi: 10.1038/sj.onc.1203910.