PMID- 11106224
OWN - NLM
STAT- MEDLINE
DCOM- 20010531
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 16
IP  - 4
DP  - 2000 Oct
TI  - Genetic aspects in sarcoidosis.
PG  - 768-80
AB  - Sarcoidosis is an immune-mediated, multiorgan, granulomatous disorder thought to 
      be triggered by an intricate combination of environmental and genetic factors. 
      Two robust lines of evidence support the hypothesis of a genetic component in the 
      pathogenesis of sarcoidosis: racial variation in its epidemiology and familial 
      clustering of cases. The relationship between epidemiology and environmental 
      factors affecting variations in sarcoidosis incidence/prevalence and presentation 
      are reviewed, as well as strategies to be pursued in the search for 
      susceptibility genes for the disorder. Pathogenic processes leading to sarcoid 
      granuloma formation and maintenance have prompted investigators interested in the 
      genetics of sarcoidosis to focus mainly on major histocompatibility complex 
      genes, and indeed a remarkable amount of data has been accumulated during the 
      last two decades. Whilst in contrast with some autoimmune disorders a clear 
      association between human leukocyte antigen (HLA) and sarcoidosis is still a 
      controversial issue, there is, however, a general agreement that some HLA genes 
      are related to phenotypic variations of the disease. Some genetic investigators 
      have focused on T-cell receptor genes, immunoglobulin genes, angiotensin 
      converting enzyme gene, chemokine genes and others. From a review of studies 
      performed in different racial and ethnic groups, a reasonable suggestion arises 
      that genetic factors are the major determinant in the racial variations in the 
      epidemiology of the disorder. This assumption is, however, so far limited by lack 
      of studies considering both genetic and environmental factors simultaneously.
FAU - Luisetti, M
AU  - Luisetti M
AD  - Clinica di Malattie dell'Apparato Respiratorio, IRCCS Policlinico San Matteo 
      Universita di Pavia, Italy.
FAU - Beretta, A
AU  - Beretta A
FAU - Casali, L
AU  - Casali L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
CIN - Eur Respir J. 2001 Apr;17(4):833. PMID: 11401082
MH  - Environmental Exposure
MH  - Humans
MH  - Risk Factors
MH  - Sarcoidosis/epidemiology/*genetics
RF  - 117
EDAT- 2000/12/06 11:00
MHDA- 2001/06/02 10:01
CRDT- 2000/12/06 11:00
PHST- 2000/12/06 11:00 [pubmed]
PHST- 2001/06/02 10:01 [medline]
PHST- 2000/12/06 11:00 [entrez]
AID - 10.1034/j.1399-3003.2000.16d31.x [doi]
PST - ppublish
SO  - Eur Respir J. 2000 Oct;16(4):768-80. doi: 10.1034/j.1399-3003.2000.16d31.x.