PMID- 11106240
OWN - NLM
STAT- MEDLINE
DCOM- 20010531
LR  - 20061115
IS  - 1078-0432 (Print)
IS  - 1078-0432 (Linking)
VI  - 6
IP  - 11
DP  - 2000 Nov
TI  - Prognostic significance of cyclin E overexpression in laryngeal squamous cell 
      carcinomas.
PG  - 4253-8
AB  - Cyclin E plays a pivotal role in the regulation of G1-S transition and relates to 
      malignant transformation of cells. However, the clinical significance of cyclin E 
      in patients with laryngeal squamous cell carcinoma (LSCC) remains unknown. We 
      examined the expression of cyclin E in 102 patients with LSCC and analyzed its 
      relation to clinicopathological parameters, cell proliferation, and clinical 
      outcome. Cyclin E overexpression was observed in 54 cases (52.94%) of LSCC and 
      was significantly correlated with the tumor site (P = 0.012), tumor size (P = 
      0.006), poor differentiation (P = 0.026), lymph node metastasis (P = 0.012), and 
      advanced stage (P = 0.002). A positive correlation between the cyclin E 
      expression and proliferative activity of tumor cells was found (r = 0.896; P < 
      0.0001). Kaplan-Meier analysis showed that shorter disease-free and overall 
      survival was significantly associated with proliferating cell nuclear antigen 
      (PCNA) overexpression and cyclin E overexpression. When PCNA and cyclin E are 
      combined, the patients with both PCNA overexpression and cyclin E overexpression 
      had the poorest prognoses when compared with the other cases. Additionally, in 
      early stage (I-II) cases, cyclin E was also revealed to possess a significant 
      prognostic role. By multivariate analysis, lymph node metastasis and cyclin E 
      overexpression were independent prognostic factors for disease-free survival, and 
      tumor size, lymph node metastasis, advanced stage, as well as cyclin E 
      overexpression were independent prognostic factors for overall survival. These 
      findings indicate that cyclin E overexpression is associated with unfavorable 
      clinicopathological parameters and represents an independent marker for cell 
      proliferation and prognosis of LSCC.
FAU - Dong, Y
AU  - Dong Y
AD  - Department of Physiology, Kagawa Medical University, Japan.
FAU - Sui, L
AU  - Sui L
FAU - Tai, Y
AU  - Tai Y
FAU - Sugimoto, K
AU  - Sugimoto K
FAU - Hirao, T
AU  - Hirao T
FAU - Tokuda, M
AU  - Tokuda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for 
      Cancer Research
JID - 9502500
RN  - 0 (Cyclin E)
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Cell Division
MH  - Cyclin E/analysis/*biosynthesis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Proliferating Cell Nuclear Antigen/analysis
MH  - Retrospective Studies
EDAT- 2000/12/06 11:00
MHDA- 2001/06/02 10:01
CRDT- 2000/12/06 11:00
PHST- 2000/12/06 11:00 [pubmed]
PHST- 2001/06/02 10:01 [medline]
PHST- 2000/12/06 11:00 [entrez]
PST - ppublish
SO  - Clin Cancer Res. 2000 Nov;6(11):4253-8.