PMID- 11106816
OWN - NLM
STAT- MEDLINE
DCOM- 20001222
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 122
IP  - 2
DP  - 2000 Oct 15
TI  - Variant intra philadelphia translocation with rearrangement of BCR-ABL and 
      ABL-BCR within the same chromosome in a patient with cALL.
PG  - 83-6
AB  - A unique variant Philadelphia translocation accompanied by the loss of the short 
      arm of chromosome 9 in a 32-year-old female with common acute lymphoblastic 
      leukemia (cALL) is described. Furthermore, supernumerary chromosome 8 material 
      was found as an insertion into the long arm of chromosome 2 and/or as ring 
      chromosomes in addition to two normal chromosomes 8. The chromosomal 
      abnormalities were identified by combined conventional chromosome banding 
      analysis and fluorescence in situ hybridization (FISH). The BCR-ABL rearrangement 
      was confirmed by FISH and reverse transcriptase-polymerase chain reaction 
      (RT-PCR) studies. Possible mechanisms leading to this variant intra Philadelphia 
      translocation are discussed. The aberrations found have prognostic implications, 
      because 9p anomalies confer an adverse effect to the already poor prognosis of 
      Philadelphia-positive ALL.
FAU - Edelhauser, M
AU  - Edelhauser M
AD  - Institut fur Medizinische Biologie der Universitat Wien, Wahringer Strasse 10, 
      1090, Wien, Austria.
FAU - Raber, W
AU  - Raber W
FAU - Mitterbauer, G
AU  - Mitterbauer G
FAU - Mannhalter, C
AU  - Mannhalter C
FAU - Lechner, K
AU  - Lechner K
FAU - Fonatsch, C
AU  - Fonatsch C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (abl-bcr fusion protein, human)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Adult
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 2/genetics
MH  - Chromosomes, Human, Pair 22/genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Chromosomes, Human, Pair 9/genetics
MH  - Female
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Oncogene Proteins, Fusion/*genetics
MH  - *Philadelphia Chromosome
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/pathology
MH  - Translocation, Genetic
EDAT- 2000/12/07 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/07 11:00
PHST- 2000/12/07 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/07 11:00 [entrez]
AID - S0165-4608(00)00267-3 [pii]
AID - 10.1016/s0165-4608(00)00267-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Oct 15;122(2):83-6. doi: 
      10.1016/s0165-4608(00)00267-3.