PMID- 11108215
OWN - NLM
STAT- MEDLINE
DCOM- 20010412
LR  - 20191104
IS  - 0278-940X (Print)
IS  - 0278-940X (Linking)
VI  - 28
IP  - 3 - 4
DP  - 2000
TI  - Improved orthopaedic bone cement formulations based on rubber toughening.
PG  - 457-61
AB  - Poly(methylmethacrylate) (PMMA) bone cements have been used for the fixation of 
      hip and knee implants since the early 1960s. Aseptic loosening, related to 
      fracture of the PMMA, continues to be the primary mode of failure for these 
      prostheses. Failed prostheses must be replaced causing additional expense and 
      patient trauma. Furthermore, the average lifetime of the revised prosthesis is 
      significantly lower than that of a primary prosthesis. Recent work by Moseley and 
      co-workers led to the development of a promising new rubber toughened cement. It 
      is comprised of a matrix of the traditional PMMA with dispersed rubber particles 
      to modify mechanical properties and, in particular, improve fracture toughness. 
      The fracture toughness of the experimental material was 167% greater than the 
      toughness of a nontoughened control; however, the elastic modulus and compressive 
      strength were reduced. The reductions in properties should not pose a clinical 
      problem based on results of the implant model reported by Moseley. More serious 
      concerns were mixing and delivery problems and high residual monomer 
      concentrations. The formulation and chemical/mechanical characterization of new 
      toughened acrylic formulations that have residual monomer levels equivalent to 
      Simplex and better mixing properties are reported.
FAU - Puckett, A D
AU  - Puckett AD
AD  - Department of Restorative Dentistry/Biomaterials, University of Mississippi 
      Medical Center, Jackson 39216, USA.
FAU - Roberts, B
AU  - Roberts B
FAU - Bu, L
AU  - Bu L
FAU - Mays, J W
AU  - Mays JW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Crit Rev Biomed Eng
JT  - Critical reviews in biomedical engineering
JID - 8208627
RN  - 0 (Bone Cements)
RN  - 0 (Methylmethacrylates)
RN  - 0 (Polystyrenes)
RN  - 25034-86-0 (styrene-methylmethacrylate copolymer)
RN  - 9006-04-6 (Rubber)
RN  - 9011-14-7 (Polymethyl Methacrylate)
SB  - IM
MH  - Bone Cements/*chemistry
MH  - Equipment Failure Analysis
MH  - Hip Prosthesis
MH  - *Materials Testing
MH  - Methylmethacrylates
MH  - Molecular Weight
MH  - Polymethyl Methacrylate/*chemistry
MH  - Polystyrenes
MH  - Rubber/*chemistry
MH  - Stress, Mechanical
EDAT- 2000/12/07 11:00
MHDA- 2001/04/17 10:01
CRDT- 2000/12/07 11:00
PHST- 2000/12/07 11:00 [pubmed]
PHST- 2001/04/17 10:01 [medline]
PHST- 2000/12/07 11:00 [entrez]
AID - 10.1615/critrevbiomedeng.v28.i34.180 [doi]
PST - ppublish
SO  - Crit Rev Biomed Eng. 2000;28(3 - 4):457-61. doi: 
      10.1615/critrevbiomedeng.v28.i34.180.