PMID- 11108829
OWN - NLM
STAT- MEDLINE
DCOM- 20010301
LR  - 20240109
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 409
IP  - 3
DP  - 2000 Dec 15
TI  - A novel anti-rheumatic drug suppresses tumor necrosis factor-alpha and augments 
      interleukin-10 in adjuvant arthritic rats.
PG  - 331-5
AB  - Tumor necrosis factor-alpha (TNF-alpha) plays an important role in the pathology 
      of rheumatoid arthritis. When 
      N-[1-(4- inverted question mark[4-(pyrimidin-2-yl)piperazin-1-yl]methyl inverted question markphenyl)cycloprop yl] acetamide 
      (Y-39041) (3-30 mg/kg) was orally administered to rats with established arthritis 
      from day 15 to day 20, hindpaw volume was significantly reduced. This inhibitory 
      activity of Y-39041 was kept up after administration was stopped. On day 17 
      Y-39041 suppressed lipopolysaccharide-induced TNF-alpha and interleukin-6 
      production in serum at doses of 3-30 mg/kg, and augmented interleukin-10 
      production at doses of 10 and 30 mg/kg. The finding that Y-39041 suppresses 
      TNF-alpha and interleukin-6 production and augments interleukin-10 production 
      could be beneficial in the therapy of chronic inflammatory diseases.
FAU - Hisadome, M
AU  - Hisadome M
AD  - Research Laboratories, Welfide Corporation, 955 Koiwai, Yoshitomi-cho, 
      Chikujo-gun, 871-8550, Fukuoka, Japan. hisadome@welfide.co.jp
FAU - Fukuda, T
AU  - Fukuda T
FAU - Sumichika, H
AU  - Sumichika H
FAU - Hanano, T
AU  - Hanano T
FAU - Adachi, K
AU  - Adachi K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Acetamides)
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Piperazines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Y 39041)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Acetamides/*therapeutic use
MH  - Animals
MH  - Antirheumatic Agents/*therapeutic use
MH  - Arthritis, Experimental/*drug therapy
MH  - Drug Evaluation, Preclinical
MH  - Hindlimb
MH  - Interleukin-10/*metabolism
MH  - Interleukin-6/*metabolism
MH  - Lipopolysaccharides
MH  - Male
MH  - Piperazines/*therapeutic use
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2000/12/08 11:00
MHDA- 2001/03/07 10:01
CRDT- 2000/12/08 11:00
PHST- 2000/12/08 11:00 [pubmed]
PHST- 2001/03/07 10:01 [medline]
PHST- 2000/12/08 11:00 [entrez]
AID - S0014299900008669 [pii]
AID - 10.1016/s0014-2999(00)00866-9 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2000 Dec 15;409(3):331-5. doi: 10.1016/s0014-2999(00)00866-9.