PMID- 11109614
OWN - NLM
STAT- MEDLINE
DCOM- 20001222
LR  - 20181130
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 72
IP  - 5
DP  - 2000
TI  - [Approaches to prediction of gastropathy development risk due to non-steroidal 
      antiinflammatory drugs].
PG  - 25-8
AB  - AIM: Examination of gastric secretion in rheumatoid arthritis (RA) patients and 
      its response to sodium diclophenak and indomethacine. MATERIALS AND METHODS: 46 
      RA patients entered the study. All of them have been long on nonsteroid 
      antiinflammatory drugs (NAID). Two groups of patients were analysed: group 
      1--free of NAID gastropathy, group 2--with NAID gastropathy. pH was followed by 
      Gastroscan system. RESULTS: The analysis of 24-h pH-grams in both groups when 
      NAID were not taken showed that in NAID gastropathy acid-forming gastric function 
      is not affected while the alkalizing function markedly declines. Indomethacine is 
      more aggressive to upper gastrointestinal tract mucosa than sodium diclophenak. 
      CONCLUSION: Dynamic intragastric pH-metry can prognosticate the risk of NAID 
      gastropathy.
FAU - Alekseeva, A V
AU  - Alekseeva AV
FAU - Murav'ev, Iu V
AU  - Murav'ev IuV
LA  - rus
PT  - Comparative Study
PT  - Journal Article
TT  - Podkhody k prognozirovaniiu riska vozniknoveniia gastropatii, vyzvannykh 
      nesteroidnymi protivovospalitel'nymi preparatami.
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 144O8QL0L1 (Diclofenac)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
MH  - Arthritis, Rheumatoid/drug therapy
MH  - Diclofenac/adverse effects
MH  - Gastric Acid/*metabolism
MH  - Gastric Mucosa/drug effects/*metabolism/pathology
MH  - Gastroscopy
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Indomethacin/adverse effects
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Stomach Diseases/*chemically induced/metabolism/pathology
EDAT- 2000/12/08 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/08 11:00
PHST- 2000/12/08 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/08 11:00 [entrez]
PST - ppublish
SO  - Ter Arkh. 2000;72(5):25-8.