PMID- 11110426
OWN - NLM
STAT- MEDLINE
DCOM- 20010322
LR  - 20190817
IS  - 0047-1828 (Print)
IS  - 0047-1828 (Linking)
VI  - 64
IP  - 11
DP  - 2000 Nov
TI  - Increased plasma antigen levels of monocyte chemoattractant protein-1 in patients 
      with restenosis after percutaneous transluminal coronary angioplasty.
PG  - 831-4
AB  - Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the 
      progression of atherosclerosis in coronary arteries. To examine whether or not 
      plasma antigen levels of MCP-1 are related to restenosis after percutaneous 
      transluminal coronary angioplasty (PTCA), the plasma antigen levels of MCP-1 were 
      measured by enzyme-linked immunosorbent assay (pg/ml) before, 24 and 48 h, and 3 
      months after elective PTCA for stable exertional angina performed between June 
      1997 and March 1998. Restenosis was defined as recurrence of stenosis greater 
      than 50% of the diameter in the dilated segment at 3-month follow-up angiography. 
      There were no differences in plasma MCP-1 antigen levels before and at 24 h after 
      PTCA between restenosis (R; n=27) and no-restenosis (N; n=43) groups (R vs N: 
      633+/-35 vs 589+/-34, and 669+/-41 vs 575+/-36 pg/ml before and at 24 h after 
      PTCA, respectively), but plasma MCP-1 antigen levels were higher at 48 h and 3 
      months after PTCA in the R than in N group (R vs N: 678+/-41 vs 558+/-35, and 
      735+/-35 vs 571+/-32 pg/ml at 48 h and 3 months after PTCA, respectively). These 
      data suggest that the MCP-1 production and macrophage accumulation in the 
      balloon-injured site is partially associated with restenosis after PTCA.
FAU - Hokimoto, S
AU  - Hokimoto S
AD  - Department of Cardiovascular Medicine, Kumamoto Central Hospital, Japan.
FAU - Ogawa, H
AU  - Ogawa H
FAU - Saito, T
AU  - Saito T
FAU - Oshima, S
AU  - Oshima S
FAU - Noda, K
AU  - Noda K
FAU - Soejima, H
AU  - Soejima H
FAU - Takazoe, K
AU  - Takazoe K
FAU - Date, H
AU  - Date H
FAU - Ishibashi, F
AU  - Ishibashi F
FAU - Nakamura, S
AU  - Nakamura S
FAU - Yasue, H
AU  - Yasue H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn Circ J
JT  - Japanese circulation journal
JID - 7806868
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Angioplasty, Balloon, Coronary/*adverse effects
MH  - Biomarkers
MH  - Chemokine CCL2/*blood
MH  - Coronary Angiography
MH  - Coronary Disease/*blood/diagnostic imaging/therapy
MH  - Coronary Vessels/injuries
MH  - Endothelium, Vascular/injuries
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Macrophages/metabolism/pathology
MH  - Male
MH  - Predictive Value of Tests
MH  - Recurrence
EDAT- 2000/12/08 11:00
MHDA- 2001/03/27 10:01
CRDT- 2000/12/08 11:00
PHST- 2000/12/08 11:00 [pubmed]
PHST- 2001/03/27 10:01 [medline]
PHST- 2000/12/08 11:00 [entrez]
AID - 10.1253/jcj.64.831 [doi]
PST - ppublish
SO  - Jpn Circ J. 2000 Nov;64(11):831-4. doi: 10.1253/jcj.64.831.