PMID- 11110575
OWN - NLM
STAT- MEDLINE
DCOM- 20010531
LR  - 20191104
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 11
IP  - 4
DP  - 2000 Nov
TI  - Soluble CD30 and CD23 in cord blood are not related to atopy in early childhood.
PG  - 220-4
AB  - Atopic disease, including atopic dermatitis (AD), is associated with a T-helper 2 
      (Th2)-dependent immune response. The cytokine receptor CD30 appears to be 
      preferentially expressed on, and its soluble form (sCD30) released by, Th2 cells. 
      Therefore, sCD30 may be a potential marker for atopic disorders. The aim of this 
      study was to test the hypothesis that the sCD30 level in cord blood could be used 
      to predict the development of atopy or AD in early childhood. In a case-control 
      study, levels of sCD30, as well as soluble low-affinity immunoglobulin E (IgE) 
      receptor (sCD23), interleukin-4 (IL-4) and IgE, were measured in cord blood in 35 
      children who subsequently developed allergic sensitization and AD before the age 
      of three, and the results were compared to those of 35 matched children without a 
      history of atopy. There was no difference in cord blood levels of sCD30 between 
      controls (32.5 U/ml; 19.7-80.1) and children with subsequent atopy and AD (32.2 
      U/ml; 22-75.9) (median; quartiles). The concentration of sCD30 showed no relation 
      to the levels of total IgE, sCD23 or IL-4. Levels of sCD23 were similar in 
      children with subsequent atopy (60.2 U/ml; 44.5-76.8) and controls (55.2 U/ml; 
      38.3-72.5), whereas IL-4 was detectable in 10 of the atopic children and in only 
      two of the controls (p <0.05). In conclusion, cord blood levels of sCD30 or sCD23 
      do not seem to be related to the subsequent development of atopy or AD at the age 
      of three.
FAU - Oymar, K
AU  - Oymar K
AD  - Department of Pediatrics, Rogaland County Hospital, Stavanger, Norway. 
      Knut.Oeymar@sir.rfk-helse.telemax.no
FAU - Laerdal, A
AU  - Laerdal A
FAU - Bjerknes, R
AU  - Bjerknes R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Ki-1 Antigen)
RN  - 0 (Receptors, IgE)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Humans
MH  - Hypersensitivity/*etiology
MH  - Immunoglobulin E/blood
MH  - Interleukin-4/blood
MH  - Ki-1 Antigen/*blood
MH  - Male
MH  - Receptors, IgE/*blood
EDAT- 2000/12/08 11:00
MHDA- 2001/06/02 10:01
CRDT- 2000/12/08 11:00
PHST- 2000/12/08 11:00 [pubmed]
PHST- 2001/06/02 10:01 [medline]
PHST- 2000/12/08 11:00 [entrez]
AID - 10.1034/j.1399-3038.2000.00094.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2000 Nov;11(4):220-4. doi: 
      10.1034/j.1399-3038.2000.00094.x.