PMID- 11110739
OWN - NLM
STAT- MEDLINE
DCOM- 20010215
LR  - 20190501
IS  - 0959-8138 (Print)
IS  - 1468-5833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 321
IP  - 7274
DP  - 2000 Dec 9
TI  - Problem solving treatment and group psychoeducation for depression: multicentre 
      randomised controlled trial. Outcomes of Depression International Network (ODIN) 
      Group.
PG  - 1450-4
AB  - OBJECTIVES: To determine the acceptability of two psychological interventions for 
      depressed adults in the community and their effect on caseness, symptoms, and 
      subjective function. DESIGN: A pragmatic multicentre randomised controlled trial, 
      stratified by centre. SETTING: Nine urban and rural communities in Finland, 
      Republic of Ireland, Norway, Spain, and the United Kingdom. PARTICIPANTS: 452 
      participants aged 18 to 65, identified through a community survey with depressive 
      or adjustment disorders according to the international classification of 
      diseases, 10th revision or Diagnostic and Statistical Manual of Mental Disorders, 
      fourth edition. INTERVENTIONS: Six individual sessions of problem solving 
      treatment (n=128), eight group sessions of the course on prevention of depression 
      (n=108), and controls (n=189). MAIN OUTCOME MEASURES: Completion rates for each 
      intervention, diagnosis of depression, and depressive symptoms and subjective 
      function. RESULTS: 63% of participants assigned to problem solving and 44% 
      assigned to prevention of depression completed their intervention. The proportion 
      of problem solving participants depressed at six months was 17% less than that 
      for controls, giving a number needed to treat of 6; the mean difference in Beck 
      depression inventory score was -2. 63 (95% confidence interval -4.95 to -0.32), 
      and there were significant improvements in SF-36 scores. For depression 
      prevention, the difference in proportions of depressed participants was 14% 
      (number needed to treat of 7); the mean difference in Beck depression inventory 
      score was -1.50 (-4.16 to 1.17), and there were significant improvements in SF-36 
      scores. Such differences were not observed at 12 months. Neither specific 
      diagnosis nor treatment with antidepressants affected outcome. CONCLUSIONS: When 
      offered to adults with depressive disorders in the community, problem solving 
      treatment was more acceptable than the course on prevention of depression. Both 
      interventions reduced caseness and improved subjective function.
FAU - Dowrick, C
AU  - Dowrick C
AD  - Department of Primary Care, University of Liverpool, Liverpool L69 3GB. 
      cfd@liv.ac.uk
FAU - Dunn, G
AU  - Dunn G
FAU - Ayuso-Mateos, J L
AU  - Ayuso-Mateos JL
FAU - Dalgard, O S
AU  - Dalgard OS
FAU - Page, H
AU  - Page H
FAU - Lehtinen, V
AU  - Lehtinen V
FAU - Casey, P
AU  - Casey P
FAU - Wilkinson, C
AU  - Wilkinson C
FAU - Vazquez-Barquero, J L
AU  - Vazquez-Barquero JL
FAU - Wilkinson, G
AU  - Wilkinson G
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Depressive Disorder/*therapy
MH  - Europe
MH  - Humans
MH  - Middle Aged
MH  - Patient Education as Topic
MH  - Patient Satisfaction
MH  - *Problem Solving
MH  - Psychotherapy/*methods
MH  - Treatment Outcome
PMC - PMC27549
EDAT- 2000/12/09 11:00
MHDA- 2001/03/03 10:01
PMCR- 2000/12/09
CRDT- 2000/12/09 11:00
PHST- 2000/12/09 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/12/09 11:00 [entrez]
PHST- 2000/12/09 00:00 [pmc-release]
AID - 10.1136/bmj.321.7274.1450 [doi]
PST - ppublish
SO  - BMJ. 2000 Dec 9;321(7274):1450-4. doi: 10.1136/bmj.321.7274.1450.