PMID- 11111066
OWN - NLM
STAT- MEDLINE
DCOM- 20010215
LR  - 20161124
IS  - 1071-5576 (Print)
IS  - 1071-5576 (Linking)
VI  - 7
IP  - 6
DP  - 2000 Nov-Dec
TI  - Magnesium sulfate and fetal plasma concentrations of epinephrine, norepinephrine, 
      and vasopressin in response to acute hypoxemia in goats.
PG  - 328-32
AB  - OBJECTIVE: We measured fetal plasma concentrations of epinephrine, 
      norepinephrine, and vasopressin during acute hypoxemia in goats and tested 
      whether hypermagnesemia altered these endocrine responses. METHODS: Five 
      chronically catheterized goat fetuses at 124-129 days' gestation were used. After 
      4 hours of infusion (magnesium or vehicle as controls), 30 minutes of hypoxemia 
      was induced by infusing nitrogen gas through a maternal tracheal catheter. Fetal 
      plasma concentrations of epinephrine, norepinephrine, and vasopressin were 
      measured before and during hypoxemia. Both magnesium sulfate and vehicle 
      infusions were performed in each animal. Repeated-measures analysis of variance 
      (ANOVA) and two-way ANOVA with post hoc test were used to determine statistical 
      significance. RESULTS: During hypoxemia, fetal PO(2) decreased significantly from 
      30 to 14 mmHg with no significant changes in fetal pH or PCO(2) in both groups. 
      Fetal heart rate was reduced significantly by hypoxemia, but to a lesser extent 
      in the magnesium group (change in decrease in fetal heart rate: 41 beats per 
      minute [bpm] in controls versus 26 bpm with magnesium). Mean blood pressure did 
      not change significantly during hypoxemia in both groups. Fetal plasma 
      concentrations of epinephrine, norepinephrine, and vasopressin significantly 
      increased from the prehypoxemic values both with magnesium and in controls. There 
      were no significant differences in these hormone concentrations between magnesium 
      and the controls. CONCLUSION: Magnesium sulfate had no effect on fetal plasma 
      concentrations of vasopressin, epinephrine, and norepinephrine during acute 
      hypoxemia.
FAU - Sameshima, H
AU  - Sameshima H
AD  - Perinatal Center, Miyazaki Medical College, Miyazaki, Japan. 
      hsameshima@fc.miyazaki-med.ac.jp
FAU - Tanaka, S
AU  - Tanaka S
FAU - Kamitomo, M
AU  - Kamitomo M
FAU - Ikenoue, T
AU  - Ikenoue T
FAU - Sakamoto, H
AU  - Sakamoto H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Soc Gynecol Investig
JT  - Journal of the Society for Gynecologic Investigation
JID - 9433806
RN  - 11000-17-2 (Vasopressins)
RN  - 7487-88-9 (Magnesium Sulfate)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Animals
MH  - Blood Gas Analysis/veterinary
MH  - Blood Pressure
MH  - Epinephrine/*blood
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Goat Diseases/*blood
MH  - Goats
MH  - Heart Rate, Fetal
MH  - Hydrogen-Ion Concentration
MH  - Hypoxia/*blood
MH  - Magnesium Sulfate/*pharmacology
MH  - Norepinephrine/*blood
MH  - Pregnancy
MH  - Vasopressins/*blood
EDAT- 2000/12/09 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/12/09 11:00
PHST- 2000/12/09 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/12/09 11:00 [entrez]
AID - S1071557600000800 [pii]
PST - ppublish
SO  - J Soc Gynecol Investig. 2000 Nov-Dec;7(6):328-32.