PMID- 11113601
OWN - NLM
STAT- MEDLINE
DCOM- 20010329
LR  - 20190910
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 35
IP  - 9-10
DP  - 2000 Dec
TI  - NMDA receptor activation in the aged rat hippocampus.
PG  - 1185-99
AB  - Age-related alterations of N-methyl-D-aspartate receptor (NMDAr) activation were 
      investigated in the CA1 field of hippocampal slices from young (3-6 months old) 
      and aged (25-33 months old) Sprague-Dawley rats by using ex vivo extracellular 
      electrophysiological recording techniques. NMDAr-mediated field excitatory 
      postsynaptic potentials (fEPSPs) were induced by electrical stimulation of 
      glutamatergic fibers in a magnesium (Mg(2+))-free medium supplemented with the 
      non-NMDAr antagonist CNQX. The fEPSPs were significantly smaller in aged rats, 
      whereas the response of presynaptic afferent fibers remained unaffected. No 
      significant age-related differences were found in the ability of Mg(2+) to 
      depress the magnitude of NMDAr-mediated fEPSPs. The responsiveness of 
      postsynaptic NMDAr to the agonist was assessed in both groups of animals. No 
      age-related differences were recorded either in the depolarizing effect of 
      bath-applied NMDA or in the magnitude of the depolarization after altering 
      extracellular Mg(2+) concentration. Finally, short-term potentiation (STP) of 
      excitatory transmission was studied in young and aged rats considering the 
      pivotal role of NMDAr in synaptic plasticity. No age-related alterations of the 
      magnitude and the time course of STP in response to 10 or 30Hz conditioning 
      stimulation were found. Because of the decrease in the magnitude of 
      NMDAr-mediated synaptic transmission in aged animals, the absence of obvious 
      modifications of synaptic plasticity suggests the occurrence of compensatory 
      mechanisms that are discussed.
FAU - Potier, B
AU  - Potier B
AD  - Dynamique des Systemes Neuroendocriniens, INSERM U159, 2ter rue d'Alesia, 75014, 
      Paris, France.
FAU - Poindessous-Jazat, F
AU  - Poindessous-Jazat F
FAU - Dutar, P
AU  - Dutar P
FAU - Billard, J M
AU  - Billard JM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Aging/*physiology
MH  - Animals
MH  - Electrophysiology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects
MH  - Hippocampus/drug effects/*physiology
MH  - In Vitro Techniques
MH  - Magnesium/pharmacology
MH  - Male
MH  - N-Methylaspartate/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Synapses/drug effects/physiology
MH  - Time Factors
EDAT- 2000/12/13 11:00
MHDA- 2001/04/03 10:01
CRDT- 2000/12/13 11:00
PHST- 2000/12/13 11:00 [pubmed]
PHST- 2001/04/03 10:01 [medline]
PHST- 2000/12/13 11:00 [entrez]
AID - S0531-5565(00)00122-4 [pii]
AID - 10.1016/s0531-5565(00)00122-4 [doi]
PST - ppublish
SO  - Exp Gerontol. 2000 Dec;35(9-10):1185-99. doi: 10.1016/s0531-5565(00)00122-4.