PMID- 11114738
OWN - NLM
STAT- MEDLINE
DCOM- 20010111
LR  - 20220316
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 19
IP  - 49
DP  - 2000 Nov 20
TI  - Met receptor tyrosine kinase: enhanced signaling through adapter proteins.
PG  - 5582-9
AB  - The Met receptor tyrosine kinase is the prototypic member of a small subfamily of 
      growth factor receptors that when activated induce mitogenic, motogenic, and 
      morphogenic cellular responses. The ligand for Met is hepatocyte growth 
      factor/scatter factor (HGF/SF) and while normal HGF/SF-Met signaling is required 
      for embryonic development, abnormal Met signaling has been strongly implicated in 
      tumorigenesis, particularly in the development of invasive and metastatic 
      phenotypes. Following ligand binding and autophosphorylation, Met transmits 
      intercellular signals using a unique multisubstrate docking site present within 
      the C-terminal end of the receptor. The multisubstrate docking site mediates the 
      binding of several adapter proteins such as Grb2, SHC, Crk/CRKL, and the large 
      adapter protein Gab1. These adapter proteins in turn recruit several signal 
      transducing proteins to form an intricate signaling complex. Analysis of how 
      these adapter proteins bind to the Met receptor and what signal transducers they 
      recruit have led to more substantial models of HGF/SF-Met signal transduction and 
      have uncovered new potential pathways that may be involved into Met mediated 
      tumor cell invasion and metastasis.
FAU - Furge, K A
AU  - Furge KA
AD  - Van Andel Research Institute, 333 Bostwick, N.E., Grand Rapids, Michigan, MI 
      49503, USA.
FAU - Zhang, Y W
AU  - Zhang YW
FAU - Vande Woude, G F
AU  - Vande Woude GF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Proto-Oncogene Proteins c-met/*metabolism
MH  - *Signal Transduction
RF  - 119
EDAT- 2000/12/15 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/15 11:00
PHST- 2000/12/15 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/15 11:00 [entrez]
AID - 10.1038/sj.onc.1203859 [doi]
PST - ppublish
SO  - Oncogene. 2000 Nov 20;19(49):5582-9. doi: 10.1038/sj.onc.1203859.