PMID- 11114845
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20030930
LR  - 20181113
IS  - 1471-2350 (Print)
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 1
DP  - 2000
TI  - Estrogen receptor alpha dinucleotide repeat polymorphism in Japanese patients 
      with autoimmune thyroid diseases.
PG  - 1
AB  - BACKGROUND: The autoimmune thyroid diseases (AITDs), comprising Graves' disease 
      (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex 
      interactions between predisposing genes and environmental triggers. 
      Susceptibility to AITDs is conferred by genes in the human leukocyte antigen 
      (HLA) and genes unlinked to HLA, including the CTLA-4 gene. Recently, an 
      association to some estrogen receptor (ER)alpha genotypes with breast cancer, 
      hypertension, osteoporosis, generalized osteoarthritis, and some autoimmune 
      diseases such as rheumatoid arthritis has been reported. We have analyzed a 
      dinucleotide (TA)n repeat polymorphism lying upstream of the human ERalpha gene 
      in patients with AITDs and in normal subjects. RESULTS: Seventeen different 
      alleles were found in 130 patients with GD, 93 patients with HT, and 190 control 
      subjects. There was no significant difference in the distributions of ERalpha 
      alleles between patients and controls. CONCLUSIONS: The present results do not 
      support an association between the ERalpha gene and AITD in the Japanese 
      population.
FAU - Ban, Y
AU  - Ban Y
AD  - Third Department of Internal Medicine, Showa University School of Medicine, 
      Tokyo, Japan. yshsban@ns2.cc.showa-u.ac.jp
FAU - Taniyama, M
AU  - Taniyama M
FAU - Tozaki, T
AU  - Tozaki T
FAU - Tomita, M
AU  - Tomita M
FAU - Ban, Y
AU  - Ban Y
LA  - eng
PT  - Journal Article
DEP - 20001123
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
PMC - PMC29093
EDAT- 2000/12/15 00:00
MHDA- 2000/12/15 00:01
PMCR- 2000/11/23
CRDT- 2000/12/15 00:00
PHST- 2000/11/01 00:00 [received]
PHST- 2000/11/23 00:00 [accepted]
PHST- 2000/12/15 00:00 [pubmed]
PHST- 2000/12/15 00:01 [medline]
PHST- 2000/12/15 00:00 [entrez]
PHST- 2000/11/23 00:00 [pmc-release]
AID - 1471-2350-1-1 [pii]
AID - 10.1186/1471-2350-1-1 [doi]
PST - ppublish
SO  - BMC Med Genet. 2000;1:1. doi: 10.1186/1471-2350-1-1. Epub 2000 Nov 23.