PMID- 11115818
OWN - NLM
STAT- MEDLINE
DCOM- 20010222
LR  - 20190501
IS  - 0017-5749 (Print)
IS  - 1458-3288 (Electronic)
IS  - 0017-5749 (Linking)
VI  - 48
IP  - 1
DP  - 2001 Jan
TI  - An exaggerated sensory component of the gastrocolonic response in patients with 
      irritable bowel syndrome.
PG  - 20-7
AB  - BACKGROUND/AIMS: Visceral hypersensitivity is a feature of the irritable bowel 
      syndrome (IBS). Postprandial symptoms are common in these patients. The effects 
      of nutrients on colonic perception in IBS are incompletely understood. SUBJECTS: 
      We studied 13 healthy subjects and 16 patients with IBS-eight had diarrhoea 
      predominant (IBS-D) and eight constipation predominant (IBS-C) IBS. METHODS: 
      Colonic perception thresholds to balloon distension and viscerosomatic referral 
      pattern were assessed before and after duodenal infusion of lipid or saline, 
      respectively. At the end of the infusions, plasma levels of gastrointestinal 
      peptides were determined. RESULTS: Lipids lowered the thresholds for first 
      sensation, gas, discomfort, and pain in the IBS group but only for gas in the 
      control group. The percent reduction in thresholds for gas and pain after lipids 
      was greater in the IBS and IBS-D groups but not in the IBS-C group compared with 
      controls. IBS patients had an increased area of referred discomfort and pain 
      after lipids compared with before infusion whereas the referral area remained 
      unchanged in controls. No group differences in colonic tone or compliance were 
      observed. In both groups higher levels of cholecystokinin, pancreatic 
      polypeptide, peptide YY, vasoactive intestinal polypeptide, and neuropeptide Y 
      were seen after lipids. Motilin levels were higher in patients and differences in 
      the subgroups were observed. Levels of corticotrophin releasing factor were lower 
      in the constipated group than in the diarrhoea group. CONCLUSIONS: Postprandial 
      symptoms in IBS patients may be explained in part by a nutrient dependent 
      exaggerated sensory component of the gastrocolonic response.
FAU - Simren, M
AU  - Simren M
AD  - Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, 
      Sweden. magnus.simren@medicine.gu.se
FAU - Abrahamsson, H
AU  - Abrahamsson H
FAU - Bjornsson, E S
AU  - Bjornsson ES
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
RN  - 0 (Dietary Fats)
RN  - 0 (Neuropeptide Y)
RN  - 106388-42-5 (Peptide YY)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 52906-92-0 (Motilin)
RN  - 59763-91-6 (Pancreatic Polypeptide)
RN  - 9011-97-6 (Cholecystokinin)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Catheterization
MH  - Cholecystokinin/blood
MH  - Colon/*physiopathology
MH  - Colonic Diseases, Functional/blood/*physiopathology/*psychology
MH  - Constipation/blood/physiopathology/psychology
MH  - Diarrhea/blood/physiopathology/psychology
MH  - Dietary Fats/*adverse effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motilin/blood
MH  - Neuropeptide Y/blood
MH  - Pain Threshold
MH  - Pancreatic Polypeptide/blood
MH  - Peptide YY/blood
MH  - Postprandial Period
MH  - Pressure
MH  - Statistics, Nonparametric
MH  - Stomach/*physiopathology
MH  - Vasoactive Intestinal Peptide/blood
PMC - PMC1728182
EDAT- 2000/12/15 11:00
MHDA- 2001/03/03 10:01
PMCR- 2004/01/01
CRDT- 2000/12/15 11:00
PHST- 2000/12/15 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/12/15 11:00 [entrez]
PHST- 2004/01/01 00:00 [pmc-release]
AID - 10.1136/gut.48.1.20 [doi]
PST - ppublish
SO  - Gut. 2001 Jan;48(1):20-7. doi: 10.1136/gut.48.1.20.