PMID- 11117577
OWN - NLM
STAT- MEDLINE
DCOM- 20010104
LR  - 20220409
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 45
IP  - 10
DP  - 2000 Oct
TI  - Are antibodies to carbonic anhydrase II specific for anti-mitochondrial 
      antibody-negative primary biliary cirrhosis?
PG  - 2018-21
AB  - Antibodies to carbonic anhydrase II (CAII) have been reported to be specific to 
      anti-mitochondrial antibody (AMA)-negative primary biliary cirrhosis (PBC). We 
      examined whether antibodies to CAII are specific for AMA-negative PBC or a 
      nonspecific response in autoimmune liver disease. Antibody assays to CAII, by 
      western immunoblot (dilution 1:200), were performed on sera from 16 AMA-negative 
      PBC patients, 21 AMA-positive PBC patients, 21 autoimmune hepatitis type 1 (AIH) 
      patients, and 18 alcoholic liver disease (ALD) patients. CAII antibody activity 
      was found in 8 of 16 (50%) of the AMA-negative PBC patients, 9 of 21 (43%) of the 
      AMA-positive PBC group, 10 of 21 (48%) of the AIH group, and in 3 of 18 (17%) of 
      the ALD control group. There was no difference in the prevalence of CAII antibody 
      reactivity between the AMA-negative PBC, AMA-positive PBC, and AIH groups. In 
      conclusion, we determined that CAII antibodies are detected with equal frequency 
      in AMA-positive PBC and AIH. Given that CAII antibodies have been reported in 
      other nonhepatic autoimmune diseases, we conclude that CAII antibodies are likely 
      a nonspecific marker of autoimmunity rather than specific for AMA-negative PBC.
FAU - Comay, D
AU  - Comay D
AD  - Department of Medicine, University of Toronto, Ontario, Canada.
FAU - Cauch-Dudek, K
AU  - Cauch-Dudek K
FAU - Hemphill, D
AU  - Hemphill D
FAU - Diamandis, E
AU  - Diamandis E
FAU - Wanless, I
AU  - Wanless I
FAU - Heathcote, E J
AU  - Heathcote EJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Autoantibodies)
RN  - EC 4.2.1.1 (Carbonic Anhydrases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibody Specificity/*immunology
MH  - Autoantibodies/*blood
MH  - Carbonic Anhydrases/*immunology
MH  - Diagnosis, Differential
MH  - Female
MH  - Hepatitis, Autoimmune/diagnosis/immunology
MH  - Humans
MH  - Liver Cirrhosis, Biliary/diagnosis/*immunology
MH  - Liver Diseases, Alcoholic/diagnosis/immunology
MH  - Male
MH  - Middle Aged
MH  - Mitochondria, Liver/*immunology
EDAT- 2000/12/16 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/16 11:00
PHST- 2000/12/16 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/16 11:00 [entrez]
AID - 10.1023/a:1005548126211 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2000 Oct;45(10):2018-21. doi: 10.1023/a:1005548126211.