PMID- 11118150
OWN - NLM
STAT- MEDLINE
DCOM- 20010111
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 290
IP  - 5499
DP  - 2000 Dec 15
TI  - Development of CD8alpha-positive dendritic cells from a common myeloid 
      progenitor.
PG  - 2152-4
AB  - Dendritic cells (DCs) are critical in both initiating adaptive immune responses 
      and maintaining tolerance to self antigens. These apparently contradictory roles 
      have been suggested to depend on different subsets of DCs that arise from either 
      myeloid or lymphoid hematopoietic origins, respectively. Although DC expression 
      of CD8alpha is attributed to a lymphoid origin, here we show that both CD8alpha+ 
      and CD8alpha- DCs can arise from clonogenic common myeloid progenitors in both 
      thymus and spleen. Thus, expression of CD8alpha is not indicative of a lymphoid 
      origin, and phenotypic and functional differences among DC subsets are likely to 
      reflect maturation status rather than ontogeny.
FAU - Traver, D
AU  - Traver D
AD  - Department of Pathology, Stanford University, Stanford, CA 94305, USA.
FAU - Akashi, K
AU  - Akashi K
FAU - Manz, M
AU  - Manz M
FAU - Merad, M
AU  - Merad M
FAU - Miyamoto, T
AU  - Miyamoto T
FAU - Engleman, E G
AU  - Engleman EG
FAU - Weissman, I L
AU  - Weissman IL
LA  - eng
GR  - 5T32 AI-07290/AI/NIAID NIH HHS/United States
GR  - CA42551/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, CD)
RN  - 0 (CD8 Antigens)
SB  - IM
MH  - Animals
MH  - Antigens, CD/analysis
MH  - B-Lymphocytes/cytology/immunology
MH  - CD8 Antigens/*analysis
MH  - Cell Lineage
MH  - Dendritic Cells/*cytology/*immunology
MH  - Hematopoietic Stem Cell Transplantation
MH  - Hematopoietic Stem Cells/cytology
MH  - Immunophenotyping
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myeloid Progenitor Cells/*cytology/transplantation
MH  - Spleen/*cytology/immunology
MH  - T-Lymphocytes/cytology/immunology
MH  - Thymus Gland/*cytology/immunology
EDAT- 2000/12/16 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/12/16 11:00
PHST- 2000/12/16 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/12/16 11:00 [entrez]
AID - 10.1126/science.290.5499.2152 [doi]
PST - ppublish
SO  - Science. 2000 Dec 15;290(5499):2152-4. doi: 10.1126/science.290.5499.2152.