PMID- 11119457
OWN - NLM
STAT- MEDLINE
DCOM- 20010315
LR  - 20220321
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Print)
IS  - 1355-6037 (Linking)
VI  - 85
IP  - 1
DP  - 2001 Jan
TI  - Assessment of left ventricular long axis contraction can detect early myocardial 
      dysfunction in asymptomatic patients with severe aortic regurgitation.
PG  - 30-6
AB  - OBJECTIVE: To identify variables that could be applied at rest to diagnose 
      subclinical ventricular dysfunction in asymptomatic patients with severe aortic 
      regurgitation. DESIGN: Cross sectional study. PATIENTS: Left ventricular long 
      axis contraction was studied using tissue Doppler and M mode echocardiography in 
      21 patients with no symptoms (New York Heart Association (NYHA) functional class 
      </= 2a) but severe aortic regurgitation (jet area/left ventricular outflow tract 
      area > 40%). MAIN OUTCOME MEASURES: Left ventricular ejection fraction (LVEF) at 
      baseline and peak exercise (Weber protocol), cardiopulmonary function, and left 
      ventricular long axis function at rest (peak systolic velocity and excursion of 
      the mitral annulus). RESULTS: In 11 patients, ejection fraction increased or did 
      not change (from mean (SD) 55 (5)% to 58 (4)%, p < 0.05) (group I); in 10 
      patients it decreased by > 5% (from 54 (4)% to 42 (5)%, p < 0.001) (group II). 
      Exercise ejection fraction was < 50% in all patients in group II. At rest, there 
      were no differences between the groups in ejection fraction, left ventricular 
      diameter indices, wall stress, and short axis contraction. However, patients in 
      group II had reduced long axis contraction compared with group I: peak systolic 
      velocity 8.6 (0.6) v 11.9 (2.2) cm/s (p < 0.001); excursion 11 (2) v 14 (2) mm (p 
      < 0.01). A resting velocity of < 9.5 cm/s was the best indicator of poor exercise 
      tolerance (sensitivity 90%, specificity 100%). CONCLUSIONS: Markers of reduced 
      long axis contraction may provide simple and reliable indices of subclinical left 
      ventricular dysfunction in asymptomatic patients with severe aortic 
      regurgitation.
FAU - Vinereanu, D
AU  - Vinereanu D
AD  - Cardiovascular Sciences Research Group, University of Wales College of Medicine, 
      Heath Park, Cardiff CF14 4XN, UK.
FAU - Ionescu, A A
AU  - Ionescu AA
FAU - Fraser, A G
AU  - Fraser AG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aortic Valve Insufficiency/*complications
MH  - Cardiomyopathies/*diagnosis/etiology
MH  - Cross-Sectional Studies
MH  - Diastole
MH  - Echocardiography
MH  - Exercise Test
MH  - Female
MH  - Heart Function Tests
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Oxygen Consumption
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/etiology
PMC - PMC1729596
EDAT- 2000/12/19 11:00
MHDA- 2001/03/17 10:01
PMCR- 2004/01/01
CRDT- 2000/12/19 11:00
PHST- 2000/12/19 11:00 [pubmed]
PHST- 2001/03/17 10:01 [medline]
PHST- 2000/12/19 11:00 [entrez]
PHST- 2004/01/01 00:00 [pmc-release]
AID - 10.1136/heart.85.1.30 [doi]
PST - ppublish
SO  - Heart. 2001 Jan;85(1):30-6. doi: 10.1136/heart.85.1.30.